二甲双胍作为传统降血糖药物,是2型糖尿病的一线治疗药物。二甲双胍通过不同作用机制可降低肿瘤发生风险。其机制主要包括激活腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK)信号通路、抑制胰岛素样生长因子(IGF-1)信号通路及抑制细胞外信号调节蛋白激酶(extracellular regulated protein kinases,ERK)信号通路等。研究资料显示:二甲双胍可延长糖尿病合并肺癌患者无进展生存期(PFS)及总生存期(OS),改善患者生存状态,提高患者生存率。但目前研究结论不完全一致。
肺癌,作为一种高发病率和高死亡率的常见呼吸系统恶性肿瘤,其中肺炎型肺癌(Pneumonic-Type Lung Carcinoma, PTLC)是周围型肺癌的一种特殊表现形式,由于其影像和临床表现与肺炎等疾病相似,容易被误诊,导致错失最佳治疗时机。本文报道了1例罕见的肺炎型肺癌,详细描述了其诊断和治疗过程。患者预后良好,目前化疗后CT扫描显示病灶明显吸收。Lung cancer, as a common respiratory malignant tumor with high morbidity and mortality, among which pneumonic-type lung carcinoma (PTLC) is a special manifestation of peripheral lung cancer, which is easily misdiagnosed due to the similarity of its imaging and clinical manifestations with those of diseases such as pneumonia, resulting in the loss of optimal treatment. In this article, we report a rare case of pneumonia-type lung carcinoma and describe its diagnosis and treatment in detail. The patient had a good prognosis, and the CT scan showed significant resorption of the lesion after the current chemotherapy.
