慢性阻塞性肺疾病(Chronic Obstructive Pulmonary Disease, COPD)是一种以气流受限和呼吸困难为特征的慢性炎症性疾病。近年来,血液生物标志物在COPD的诊断、病情评估和治疗监测等方面显示出重要的潜力。血液生物标志物在COPD研究中有许多重要进展,许多研究重点关注了C反应蛋白(C-Reactive Protein, CRP)、白介素-6 (Interleukin-6, IL-6)、肿瘤坏死因子-α (Tumor Necrosis Factor-α, TNF-α)、嗜酸性粒细胞、中性粒细胞与淋巴细胞比值(Nneutrophil-to-Lymphocyte Ratio, NLR)等炎症标志物,以及其他相关标志物如纤维蛋白原、D-二聚体和胱抑素C等。通过总结现有研究成果,可以探讨这些标志物在COPD中的临床应用价值及其在疾病机制研究中的意义,进一步的研究有望揭示更多具有临床意义的生物标志物。Chronic obstructive pulmonary disease is a chronic inflammatory disease characterized by airflow limitation and dyspnea. In recent years, blood biomarkers have shown significant potential in the diagnosis, disease assessment and treatment monitoring of COPD. There have been many important advances in blood biomarkers in COPD research, with many studies focusing on inflammatory markers such as C-reactive protein, interleukin-6, tumor necrosis factor-α, eosinophils, and neutrophil-to-lymphocyte ratio, as well as other related markers such as fibrinogen, D-dimer and cystatin C. By summarizing the existing research results, the clinical application value of these markers in COPD and their significance in the study of disease mechanisms can be explored, and further studies are expected to reveal more biomarkers with clinical significance.
