搜索到23054篇“ PATCH“的相关文章
疝修复补片:材料设计与应用的最新进展
2025年
背景:与传统的缝合方式相比,采用补片修复腹壁缺陷的无张力疝修补手术能有效减少术后疼痛和疝气复发率,已经成为近年来治疗腹疝的首选方法。目的:归纳总结不同疝修复补片在应用过程中的优缺点。方法:以“腹壁缺损,疝气补片,疝气治疗”为中文检索词,以“abdominal wall defect,hernia patches,hernia treatment”为英文检索词,分别检索中国知网、谷歌学术和PubMed数据库,检索时限主要为2018年1月至2024年2月,同时采用少数经典的早期文献以概述疝修复补片的发展历程,通过阅读题目和摘要进行初步筛选,排除与疝修复材料相关性较低的文献,最终纳入90篇文献进行归纳总结。结果与结论:根据制备材料的不同可以将疝修复补片分为不可吸收人工合成补片、可吸收人工合成补片、天然高分子补片和复合补片。不可吸收补片具有较高的机械强度,有益于疝气区域的组织愈合,但体内长期存在的补片可能会引发身体的免疫反应,导致炎症和疼痛。可吸收人工合成补片与天然高分子补片具有良好的组织相容性、降解性,但机械强度不稳定。复合材料补片继承了传统不可吸收补片优良的机械性能,同时通过可吸收部分的设计降低了一些并发症发生的风险。在疝修复补片的后续研究中,科研人员应重点关注如何将新技术与复合补片结合起来,形成多功能的疝修复补片。
陈静宇洪阁郭宁刘天军
关键词:腹壁缺损聚丙烯疝气复合补片
In vivo femtosecond laser nanosurgery of the cell wall enabling patch-clamp measurements on filamentous fungi
2024年
Studying the membrane physiology of filamentous fungi is key to understanding their interactions with the environment and crucial for developing new therapeutic strategies for disease-causing pathogens.However,their plasma membrane has been inaccessible for a micron-sized patch-clamp pipette for pA current recordings due to the rigid chitinous cell wall.Here,we report the first femtosecond IR laser nanosurgery of the cell wall of the filamentous fungi,which enabled patch-clamp measurements on protoplasts released from hyphae.A reproducible and highly precise(diffraction-limited,submicron resolution)method for obtaining viable released protoplasts was developed.Protoplast release from the nanosurgery-generated incisions in the cell wall was achieved from different regions of the hyphae.The plasma membrane of the obtained protoplasts formed tight and high-resistance(GΩ)contacts with the recording pipette.The entire nanosurgical procedure followed by the patch-clamp technique could be completed in less than 1 hour.Compared to previous studies using heterologously expressed channels,this technique provides the opportunity to identify new ionic currents and to study the properties of the ion channels in the protoplasts of filamentous fungi in their native environment.
Tanja PajićKatarina StevanovićNataša V.TodorovićAleksandar J.KrmpotMiroslav ŽivićSvetlana Savić-ŠevićSteva M.LevićMarina StanićDejan PantelićBrana JelenkovićMihailo D.Rabasović
关键词:PATCHRECORDING
溶剂型冷补沥青混合料路用性能研究
2024年
基于相似相溶原理和溶剂挥发性筛选出3种有机溶剂,与线型SBS改性剂、SK70#A级沥青制得自制溶剂型冷补沥青,采用单纯形重心设计法确定各组份最佳组成水平,通过旋转黏度、黏附性、储存稳定性、挥发性指标评价其性能。依据经验公式法与纸迹法确定冷补料油石比,早期强度优选其成型与养生工艺,对比考察自制型与a型、ZY型、乳化型3种冷补料路用性能差异。结果表明,沥青冷补液固含量65%、稀释剂35%、线型SBS掺量3%时上下旋转黏度差值为968 MPa·s、3 d挥发量为7.3%、黏附性达到水煮法5级,冷补液性能最佳;LB级配冷补料最佳油石比为4.5%,二次击实、60℃养生成型早期强度达到9.53 kN且2 d内强度形成,内掺1%水泥改良级配后冷补料早期强度显著提升至13.44 kN,表明内掺水泥可有效提高溶剂型冷补料早期强度;自制型冷补料相较于a型、ZY型溶剂型冷补料具有更优异的路用性能,且残留稳定度达到95%,优于乳化型冷补料,同时也克服了常规溶剂型冷补料早期强度形成慢、耐久性差等不足。
李子豪徐心硕
关键词:道路与铁道工程冷补沥青冷补沥青混合料
Ginger oil-loaded transdermal adhesive patch treats post-traumatic stress disorder
2024年
Objective To find a viable alternative to reduce the number of doses required for the patients with post-traumatic stress disorder(PTSD),and to improve efficacy and patient compliance.Methods In this study,we used ginger oil,a phytochemical with potential therapeutic properties,to prepare ginger oil patches.High-performance liquid chromatography(HPLC)was used to quantify the main active component of ginger oil,6-gingerol.Transdermal absorption experiments were conducted to optimize the various pressure-sensitive adhesives and permeation enhancers,including their type and concentration.Subsequently,the ginger oil patches were optimized and subjected to content determination and property evaluations.A PTSD mouse model was established using the foot-shock method.The therapeutic effect of ginger oil patches on PTSD was assessed through pathological sections,behavioral tests,and the evaluation of biomarkers such as tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),brain-derived neurotrophic factor(BDNF),and melatonin(MT).Results The results demonstrated that ginger oil patches exerted therapeutic effects against PTSD by inhibiting inflammatory responses and modulating MT and BDNF levels.Pharmacokinetic experiments revealed that ginger oil patches maintained a stable blood drug concentration for at least one day,addressing the rapid metabolism drawback of 6-gingerol and enhancing its therapeutic efficacy.Conclusions Ginger oil can be prepared as a transdermal drug patch that meets these requirements,and the bioavailability of the prepared patch is better than that of oral administration.It can improve PTSD with good patient compliance and ease of administration.Therefore,it is a promising therapeutic formulation for the treatment of PTSD.
Xingshuang SongYizhi ZhangZiyan TangJing DaiYanping WuGuiyu HuangHong NiuYaxin WangXu JinLina Du
关键词:6-GINGEROL
A Simple Egg Membrane Patch Bridging Method for Repairing Tympanic Membrane Perforation
2024年
Objective:To analyze the clinical effect of a simple egg membrane patch bridging method in repairing tympanic membrane perforation.Methods:A total of 93 tympanic membrane perforation patients admitted to the hospital between September 2022 and October 2023 were selected and divided into two groups according to the random number table method.The control group implemented the conventional treatment(n=46 cases),and the patch group adopted the simple egg membrane patch bridging method(n=47 cases).The healing rate of the tympanic membrane,the air-bone gap,the air conduction hearing threshold,the dry ear rate,and the incidence of complications in both groups were compared before and after treatment.Results:The healing rate of the tympanic membrane in the patch group was significantly higher than that of the control group(95.75%vs.76.09%),with P<0.05;there was no difference in the air-bone gap and air conduction hearing threshold levels between the two groups before treatment(P>0.05),and the hearing indexes of the patch group were significantly lower than those of the control group 3 months after treatment(P<0.05);the dry ear rate in the patch group was significantly higher than that of the control group after treatment(85.11%vs.67.39%),and the total incidence of complications was also significantly lower than that of the control group(6.38%vs.21.74%),with P<0.05.Conclusion:The simple egg membrane patch bridging method is effective in repairing tympanic membrane perforation,which can effectively improve patients’hearing levels and reduce the occurrence of post-treatment complications.Thus,it is worth popularizing and applying in the clinic.
Xing HuangXuping WangBin LiLumei ShaoPing Li
Treatment of 198 Cases of Thyroid Nodules with Sanying Capsule Combined with Xiaoying Patch
2024年
[Objectives]To observe the clinical efficacy of Sanying capsule combined with Xiaoying Patch in treating thyroid nodule(TN).[Methods]Two groups were treated similarly,with 200 cases in the control group undergoing basic treatment for 12 weeks and 198 cases in the observation group receiving Sanying capsule combined with Xiaoying patches for the same duration.The clinical symptoms,number of nodules,diameter of the largest nodule,and maximum reduction of nodules were observed before and after treatment.A control analysis was performed,and the underlying mechanisms were explored.[Results]The primary symptoms of the observation group exhibited a more favorable improvement than those of the control group.Additionally,the number of nodules decreased,the diameter of the largest nodule decreased,and the maximum reduction of nodules decreased in both groups following treatment.However,the observation group demonstrated a more pronounced improvement than the control group(P<0.05).[Conclusions]The combination of Sanying capsule and Xiaoying patch has been demonstrated to be an effective treatment for TN,with a high degree of reliability in terms of safety.
Shujing SHIMingyue YANGYue HAOHaihui ZHUYan QIN
关键词:THYROIDNODULECAPSULEPATCHCLINICALEFFICACY
Cardiac-Adaptive Conductive Hydrogel Patch Enabling Construction of Mechanical–Electrical Anisotropic Microenvironment for Heart Repair
2024年
The biomimetic construction of a microstructural–mechanical–electrical anisotropic microenvironment adaptive to the native cardiac tissue is essential to repair myocardial infarction(MI).Inspired by the 3D anisotropic characteristic of the natural fish swim bladder(FSB),a novel flexible,anisotropic,and conductive hydrogel was developed for tissue-specific adaptation to the anisotropic structural,conductive,and mechanical features of the native cardiac extracellular matrix.The results revealed that the originally stiff,homogeneous FSB film was tailored to a highly flexible anisotropic hydrogel,enabling its potential as a functional engineered cardiac patch(ECP).In vitro and in vivo experiments demonstrated the enhanced electrophysiological activity,maturation,elongation,and orientation of cardiomyocytes(CMs),and marked MI repair performance with reduced CM apoptosis and myocardial fibrosis,thereby promoting cell retention,myogenesis,and vascularization,as well as improving electrical integration.Our findings offer a potential strategy for functional ECP and provides a novel strategy to bionically simulate the complex cardiac repair environment.
Xiaoping SongJifeng ZhangSi ShenDan LiuJie ZhangWenming YinGenlan YeLeyu WangLiu CaiHonghao HouXiaozhong Qiu
关键词:BLADDERPATCH
Scheme Based on Multi-Level Patch Attention and Lesion Localization for Diabetic Retinopathy Grading
2024年
Early screening of diabetes retinopathy(DR)plays an important role in preventing irreversible blindness.Existing research has failed to fully explore effective DR lesion information in fundus maps.Besides,traditional attention schemes have not considered the impact of lesion type differences on grading,resulting in unreasonable extraction of important lesion features.Therefore,this paper proposes a DR diagnosis scheme that integrates a multi-level patch attention generator(MPAG)and a lesion localization module(LLM).Firstly,MPAGis used to predict patches of different sizes and generate a weighted attention map based on the prediction score and the types of lesions contained in the patches,fully considering the impact of lesion type differences on grading,solving the problem that the attention maps of lesions cannot be further refined and then adapted to the final DR diagnosis task.Secondly,the LLM generates a global attention map based on localization.Finally,the weighted attention map and global attention map are weighted with the fundus map to fully explore effective DR lesion information and increase the attention of the classification network to lesion details.This paper demonstrates the effectiveness of the proposed method through extensive experiments on the public DDR dataset,obtaining an accuracy of 0.8064.
Zhuoqun XiaHangyu HuWenjing LiQisheng JiangLan PuYicong ShuArun Kumar Sangaiah
Chlorogenic acid supported strontium polyphenol networks ensemble microneedle patch to promote diabetic wound healing
2024年
Delayed or non-healing of diabetic wounds is a significant complication,often attributed to high glucose-induced M1 macrophage accumulation,impaired angiogenesis,and reactive oxygen species(ROS)buildup.Addressing this,we introduced a strontium polyphenol network microneedle patch(SrC-MPNs@MN-PP)for percutaneous drug delivery.This patch,formulated with polymer poly(γ-glutamic acid)(γ-PGA)and epsilon-poly-l-lysine(ε-PLL),incorporates strontium polyphenol networks(SrC-MPNs).The release of chlorogenic acid(CGA)from SrC-MPNs not only neutralizes ROS,but strontium ions also foster angiogen-esis.Consequently,SrC-MPNs@MN-PP can ameliorate the diabetic wound microenvironment and expedite healing.
Peizhe LiQiaoling LiuMengyu PeiYuci GanYan GongChuchen GongPei WangMingsong WangXiansong WangDa-Peng YangBo LiangGuangyu Ji
关键词:STRONTIUM
Evaluation of the Efficacy of Auricular Acupoint Pressure Patch Combined with Modified Huangqi Decoction in Treating Diabetic Nephropathy
2024年
Objective:To explore the efficacy of auricular acupoint pressure patch combined with modified Huangqi Decoction in treating diabetic nephropathy.Methods:60 patients with diabetic nephropathy treated in our hospital from January 2021 to December 2022 were selected for this study.The patients were randomly divided into two groups using the random number table method,with 30 patients in each group.Among them,the control group was treated with conventional Western medicine,while the experimental group was treated with auricular acupoint pressure patches combined with modified Huangqi Decoction.The patients’fasting blood glucose(FPG),2-hour postprandial blood glucose(2hPG),glycated hemoglobin(HbA1c),urinary protein quantification,urea nitrogen(BUN),serum creatinine(SCr),and other indicators were detected and recorded before and after treatment.Results:Before treatment,there was no statistically significant difference in the FPG,the 2hPG,and the HbA1c between the two groups of patients(P>0.05);after treatment,the FPG,the 2hPG,and the HbA1c of the patients in the experimental group were significantly lower than those in the control group(P<0.05).Before treatment,there was no statistically significant difference in the urinary protein quantification,the BUN,and the SCr between the two groups of patients(P>0.05);after treatment,the urinary protein quantification,BUN,and SCr of the patients in the experimental group were significantly lower than those in the control group(P<0.05).The experimental group showed better improvement in symptoms such as fatigue,backache,and frequency of nocturia(P<0.05).Conclusion:Auricular acupoint pressure patch combined with modified Huangqi Decoction effectively treats diabetic nephropathy and it helps control blood sugar and renal function indicators and improve clinical symptoms,therefore improving the patients’quality of life.
Ying Wang

相关作者

向宇
作品数:190被引量:455H指数:11
供职机构:广西科技大学
研究主题:近场声全息 精细积分法 波叠加法 声场 传递矩阵法
何伟
作品数:7被引量:7H指数:2
供职机构:广西科技大学
研究主题:近场声全息 PATCH 快速FOURIER变换 波叠加法 声场重建
徐亮
作品数:98被引量:141H指数:8
供职机构:合肥工业大学
研究主题:近场声全息 声源 测量面 声场 声压
朱海潮
作品数:116被引量:425H指数:10
供职机构:中国人民解放军海军工程大学
研究主题:声辐射模态 近场声全息 背腔 振动与波 声辐射
毕传兴
作品数:255被引量:466H指数:15
供职机构:合肥工业大学
研究主题:近场声全息 声场 声压 传声器 测量面