The intelligent optimization of a multi-objective evolutionary algorithm is combined with a gradient algorithm. The hybrid multi-objective gradient algorithm is framed by the real number. Test functions are used to analyze the efficiency of the algorithm. In the simulation case of the water phantom, the algorithm is applied to an inverse planning process of intensity modulated radiation treatment （IMRT）. The objective functions of planning target volume （PTV） and normal tissue （NT） are based on the average dose distribution. The obtained intensity profile shows that the hybrid multi-objective gradient algorithm saves the computational time and has good accuracy, thus meeting the requirements of practical applications.
