针对高校药学专业课程教学缺乏顶层设计,与专业技能、产业发展、市场需求结合不够紧密等问题,采用职业教育与产业发展、科学研究与教育教学有机融合,建设高校药学专业课程体系。协同为国培育人才的建设机制,从理实课程内容重构、教科研平台搭建、以赛促产科教三维度实施高校药学专业“产科教融汇”课程体系教学改革,以素质教育、专业教育、创新教育为基础,构建多方育人平台,培养“有知识、有技能、会创新、能创业”的技能应用型创新人才。In view of the problems of the lack of top-level design in the curriculum teaching of pharmacy specialty in colleges and the lack of close connection with professional skills, industrial development, and market demand, the curriculum system of pharmaceutical specialty in colleges and universities is constructed by the organic integration of vocational education and industrial development, scientific research and education. The teaching reform of the “integration of obstetrics and education” course system of pharmacy specialty in colleges and universities is carried out from three aspects: reconstruction of practical curriculum content, construction of teaching and research platform and promotion of obstetrics and education by competition, on the basis of a well-rounded education, professional education, and innovation education, a multi-party education platform will be built to cultivate “knowledge-based, skill-based, innovative and entrepreneurial” innovative talents.
目的:研究中国汉族人群中内皮一氧化氮合酶(endothelial nitric oxide synthase,eNOS)rs1799983G>T基因多态性与先天性心脏病易感性的关系。方法:采用以医院为基础的病例-对照研究,采用基质辅助激光解吸电离飞行时间质谱(matrix-assisted laser desorption/ionization time-of-flight mass spectrometry,MALDI-TOFMS)技术分析120例法洛四联症(tetralogy of fallot,TOF)患者(TOF组)、124例大动脉转位(transposition of the great arteries,TGA)患者(TGA组)和136例非先天性疾病患者(对照组)eNOSrs1799983G>T基因多态性,计算各种基因型的先天性心脏病发生风险及其95%可信区间。结果:eNOSrs1799983G>T基因多态三种基因型GG、GT、TT在TOF组、TGA组和对照组的频率分别为77.1%(GG)、21.2%(GT)、1.7%(TT),80.5%(GG)、19.5%(GT)、0%(TT)和82.2%(GG)、17.8%(GT)、0%(TT),Logistic回归分析发现与携带eNOSrs1799983GG基因型的个体相比较,携带eNOSrs1799983GT等位基因型与TOF和TGA的发病风险无明显相关[(OR=1.27,95%CI=0.68～2.37)和(OR=1.12,95%CI=0.60～2.10)]。结论:eNOSrs1799983G>T基因多态性可能不是先天性心脏病发生的危险因素,需要进一步研究证实。
