Objective To investigate the clinical significance for hollow needle aspiration in breast cancer diagnosis.Method Aspiration was conducted in 47 cases of breast tumors of size 1.8cm to 5.0cm using fine needle and 14G hollow needle.Result The result of fine needle aspiration cytology showed that breast cancer was diagnosed in 15 cases,12 cases were suspicious,and 20 cases were indefinite.The result of hollow needle aspiration pathology showed that 32 cases(68%) had moderate-differentiated infiltrating duct-carcinoma,8 cases(17%) had poor-differentiated infiltrating duct-carcinoma,2 cases had medullar carcinoma medullar carcinoma,5 cases had benign lesion?Conclusion The accuracy rate of hollow needle aspiration pathology is very high,because it gets a lot of tissue.
目的探讨乳腺浸润性导管癌组织中DNA依赖蛋白激酶(DNA dependent protein kinase,DNA-PK)的催化亚单位DNA-PKcs的表达变化情况与病理分级的关系.方法采用免疫组化SP法检测37例Ⅰ级分化乳腺癌组织,44例Ⅱ级分化乳腺癌组织及39例Ⅲ级分化乳腺癌组织中的DNA-PKcs的表达情况.结果DNA-PKcs在Ⅰ级分化乳腺癌组织中呈高表达,在Ⅱ级分化乳腺癌组织中的表达有降低趋势(与Ⅰ级分化乳腺癌组织比较P>0.05,与Ⅲ级分化乳腺癌组织比较P<0.01),在Ⅲ级分化乳腺癌组织中的表达明显低于Ⅰ级分化乳腺癌(P<0.01).结论DNA-PKcs在乳腺癌组织中的表达情况是随着乳腺癌的病理分级变化而变化的,从高分化癌到中分化癌到低分化癌呈逐渐降低趋势,DNA-PKcs与乳腺癌的预后有一定相关性,可能成为一个判断乳腺癌预后的分子生物学指标.
