α-Hydroxy ketones are frequently involved in biologically important compounds and,therefore,the determination of the stereochemistry of these structural elements has attracted the attention in natural products chemistry.In this paper a simpler Mosher′s method was developed from the modified Mosher′s method.It only need one configuration of MTPA to determine the absolute configurations of four α-hydroxy ketones with their（S）-and（R）-MTPA esters using（）1H NMR.The signals of protons on the same side with phenyl ring will be in the higher field than those of on the different side ones.Consequently according to the model the main configuration of compounds 1,2,3 and 4 were determined as S,R,R and S, respectively.
Aim To investigate the NMR spectroscopy of amlodipine and risperidone.Methods 1D NMR and 2D NMR experimental techniques of gCOSY, gHSQC and gHMBC were wsed. Results Theassignments of the ~1H and ^(13) C NMR data for the two drugs were performed and confirmed by theevidence of J_(HF) and J_(CF). Conclusion The structures of amlodipine and risperidone wereconfirmed by careful analysis of regular 1D and 2D NMR spectroscopy.
