目的开发一种新的双对比度快速自旋回波(DFSE)序列。方法基于双回波序列和快速自旋回波(FSE)序列,探讨DFSE序列的原理,用Visual C++设计可控参数的用户界面,编译调试DFSE序列。在Anke Medical Supervan1.5T超导MR系统上分别进行FSE及DFSE序列扫描,得到头部及膝部的质子密度加权像(PDWI)及T2WI。结果与FSE序列对比,DFSE序列用一个回波链生成PDWI及T2WI,成像速度显著提高,图像质量能够满足临床诊断要求。结论与FSE相比,DFSE是一种更快速可行的方法,一次扫描可同时获得PDWI和T2WI,且图像质量具有较好的鲁棒性。
To evaluate the effect of the positive-indefinite matrix on the diffusion tensor-derived parameters, a modified algorithm is proposed for calculating these parameters. Magnetic resonance （MR） diffusion tensor images of five healthy volunteers are collected. The diffusion sensitive gradient magnetic fields are applied along 25 directions and the diffusion weighting value is 1 000 s/mm^2. Many positive-indefinite diffusion tensors can be found in the white matter area, such as the genu and the splenium of corpus callosum. Due to the positive-indefinite matrix, the mean diffusivity （MD） and the fractional anisotropy （FA） are under-estimated and over-estimated by using the conventional algorithm. Thus, the conventional algorithm is modified by using the absolute values of all eigenvalues. Results show that both the robustness and the reliability for deriving these parameters are improved by the modified algorithm.
