The objective of the study is to study the impact of pharmaceutical care on medication compliance in asthmatic children. The results will be used to further develop the pharmaceutical care delivered by pharmacists for asthmatic children, and to promote children's asthma control in China. The study was conducted in outpatient department of Beijing Children's Hospital from Mar. to Sept., 2009. Asthmatic children (101) were randomly divided into two groups: the intervention group that received routine treatment and complete pharmaceutical care provided by pharmacists and the control group that received routine treatment only. Questionnaires were distributed to both groups and responses were analyzed statistically. Our results showed that the percentage of children using medication following doctor's instructions in the intervention group was significantly higher than that in the control group (66.67% and 36.00%, respectively); the percentage of children correctly using inhaler devices in the intervention group was significantly higher than that in the control group (78.26% and 32.84%, respectively); children and care givers of the intervention group had significantly more knowledge about medication compliance. In conclusion, the pharmaceutical care provided by pharmacists could improve medication compliance of asthmatic children, and it would be desirable to further develop the pharmaceutical care for asthmatic children across China.