An 82-year-old man was presented with dizziness for 30 years and progressive severity of nausea for one month. He was diagnosed as hypertension. He stopped taking antihypertensive drugs one year before the present hospitalization. The man was given zolpidem 10mg, once per night by mouth due to insomnia. 20 minutes after the second administration, the patient developed abnormal behavior and incorrect response. Physical examination showed inabilities of orientation, calculation and memory, mild stiff neck and positive Hoffmann sign. The man had no family history of mental disorders in the past. The above symptoms did not recur after withdrawal of zolpidem. It seems reasonable to link his symptoms to zolpidem treatment.
