Objective: To investigate the expression levels and significance of TFPI, uPA, uPAR and PAI in malignant patients. Methods: The levels of TFPI, uPA and uPAR were measured by using ELISA and the level of PAI was determined by method of chromogenic substrates in 44 patients with malignant solid tumors (group A1) and 30 patients with acute leukemia (AL, group A2). Results: The levels of TFPI, uPA, and uPAR in group A1 were higher than those in normal control group (group B). TFPI, uPAR levels in group A2 were higher than those in group B, while the level of PAI in group A2 was lower than that in group B. Among the groups, TFPI was increased in the combined infection group; PAI decreased in the hemorrhage group; TFPI, uPA, uPAR and PAI increased in relapsing and metastasis group; TFPI decreased in one-week dead group, while uPA and uPAR increased. Conclusion: The patients with malignant solid tumor and AL had different anticoagulation or fibrinolysis states. TFPI, uPA, Upar and PAI can be used to evaluate the disease condition and the prognosis.
Aim To evaluate the efficacy and cost-effectiveness of one-week regiment of quadruple and triple therapy containing:Lansoprazle(L),colloidal bismuth subciteate(B),amoxicillin(A),metrnidozole(M) and furazolidone(F).Methods 227 patients with duodenal ulcer(DU) or non-ulcer dyspepsia (NUD) confirmed by endoscopy were received LAFB,LAM or LAF,twice daily for 7 days.Endoscopy was performed in DU and 14 C-UBT was performed in NUD 4 weeks after completion of treatment.Results (1)The eradication rate of H.pylori by LAFB,LAM and LAF were 96.30%,84.51% and 70.59% respectively(LAFB vs LAF and LAF,P<0.05;LAFB vs LAM P<0.01).The healing rate of DU had no difference between three regiment P<0.05).The cost-effectiveness analysis on eradication of H.pylori showed that cost/effectiveness (C/E) of LAFB is the lowest.(2)The healing rate of DU ulcer in H.pylori eradicated patients was higher than that in uneradicated ones(98.94% vs 50%,P<0.01).The rate of ulcer recurrent of year was lower in H.pylori eradicated patients than that in uneradicated patients(2.15% vs 71.42%,P<0.01).(3)The rate of relieving symptom and recurrenting symptom in one year had no difference between H.pylori eradicated patients and uneradicated patiens in NUD(71.74% vs 70% and 53.03 vs 50,P>0.05).Conclusions The efficacy of one week regiment of quadruple therapy is higher than that in triple therapy but the side effect was not higher.The higher eradication rate is caused by combination of furazolidone,bacause it is low resis tant to H.pylori.It is also a cost-saving strategy.Eradication of H.pylori infection could improve ulcer healing and decrease the rate of ulcer recurrent but is not likely to relieve symptomes in NUD patients.
