目的:研究针刺治疗原发性痛经的脑功能机理。方法:运用静息态功能磁共振成像(resting-state functional magnetic resonance imaging,Rf MRI)技术,在16名原发性痛经患者月经来潮的第1或第2天小腹疼痛时对其进行静息态扫描(Rest1,R1)、针刺双侧三阴交和地机穴后留针状态扫描(Acupuncture,AP)、去针后第2次静息态扫描(Rest2,R2)。应用低频振荡振幅(amplitude of low frequency fluctuation,ALFF)作为测量指标,对采集的Rf MRI数据进行相关的处理与统计分析。结果:(1)针刺后患者疼痛值(VAS评分)比针刺前明显降低(P<0.01);(2)R2与AP配对t检验结果显示:ALFF信号减弱(R2
目的观察针刺手太阴肺经腧穴引起的大脑自发神经活动低频振荡振幅(amplitude of low frequency fluctuations,ALFF)变化,初步探索手太阴肺经的脑功能网络。方法运用功能磁共振成像(functional magnetic resonance imaging,fMRI)技术,对16名健康志愿者进行纯静息态扫描(Rest1,R1)和针刺左侧手太阴肺经全经腧穴后留针状态扫描(acupuncture,AP)。对采集的fMRI数据均进行个体ALFF图像计算。结果R1状态下,右侧楔前叶、左侧顶下小叶、双侧额中回、双侧颞上回、左侧额下回、左侧额上回、左侧额内侧回等脑区表现出显著的ALFF增强。AP状态下,ALFF显著增强的脑区出现在右侧楔前叶、双侧额上回、小脑、双侧额中回、右侧额内侧回等。与R1状态比较,针刺手太阴肺经使ALFF在右侧胼胝体下回、右侧额下回显著增强,而在右侧中央后回、左楔叶、左侧颞上回、左侧颞中回等脑区则显著降低。结论针刺肺经腧穴会显著改变大脑皮层固有活动状态,尤其是右侧半球的胼胝体下回、额下回等区域ALFF显著增强。
Through study on articles of fMRI and acupuncture-moxibustion of the recent 10 years, application of fMRI on specificity studies of meridians and acupoints such as comparison of single acupoint, point group, various manipulations, essence of needling sensation and indications of acupuncture, etc. were summarized. And it is held that the future study should be focused on the entire meridian. The principle of the relationship among meridians, the centre nerve and Zang-fu organs should be explored as well at a new level so as to promote the further studies on essence of meridian.
目的观察针刺手厥阴心包经全经腧穴对健康人静息态(rest1,R1)脑功能磁共振成像低频振幅的影响。方法对16名健康受试者依次进行结构像T1、T2扫描和功能像磁共振成像扫描,功能像包括第1次R1扫描,扫描时间为8 min 6 s和针刺手厥阴心包经全经腧穴后留针状态(acupuncture,AP)扫描,扫描时间为8 min 6 s。对采集的结构像和功能像fMRI数据都进行格式转换和统计分析。结果 R1状态下,ALFF信号活跃的脑区:双侧额上回、额内侧回、枕中回、楔前叶、颞上回、扣带回。AP状态下ALFF信号活跃的脑区:双侧额上回、额内侧回、颞中回、左侧梭状回、楔前叶、后扣带回、小脑山坡部。与R1状态比较,针刺心包经使得ALFF信号明显差异的脑区:双侧楔叶、楔前叶、左侧后扣带回、右侧枕中回、右侧枕叶舌回。结论针刺手厥阴心包经全经腧穴后会显著改变大脑皮层固有活动状态,尤其是双侧额上回、额内侧回、楔前叶的激活。
