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复方萘酚喹对伯氏疟原虫ANKA株红内期超微结构的影响被引量:2
2000年
为观察复方萘酚喹及其各单药 (磷酸萘酚哇、双氢青蒿素、甲氧苄啶 )对伯氏疟原虫ANKA株红内期超微结构的影响 ,将感染伯氏疟原虫ANKA株的小鼠分别以复方萘酚喹 2 6 0mg·kg- 1·d- 1× 1d (内含磷酸萘酚喹 149mg、双氢青蒿素 37mg、甲氧苄啶 74mg) ,磷酸萘酚喹 149mg·kg- 1·d- 1× 1d ,双氢青蒿素 180mg·kg- 1·d- 1× 1d和甲氧苄啶 1152mg·kg- 1·d- 1× 1d灌胃给药。给药后 1、 2、 4、 8、 12和 2 4h ,采血作标本 ,经包埋 ,切片 ,染色后 ,用电镜镜检。结果 :复方萘酚喹于给药 2h后多数晚期滋养体出现质膜肿胀、破裂 ,有的呈空腔状 ;食物泡膜肿胀 ;线粒体膜肿胀、分层、剥离 ;色素颗粒变形。给药 4h后进一步加剧。 8h后小部分晚期滋养体结构已经融化崩解 ,内容物结构模糊。 12h后绝大多数晚期滋养体结构已完全破坏或消失。结论 :复方萘酚喹对伯氏疟原虫红内期超微结构的影响较其组分中各单药起效更快、力度更强和作用相对彻底。
袁捷陈沛泉杜巧云李国桥陈林雷娓娓杨冬娣
关键词:疟疾药物疗法超微结构
Histopathological changes of Macaca mulatta infected with Plasmodium knowlesi
2001年
Objective To study the histopathological changes of relevant intemal organs of Macaca mulatta infected with Plasmodium knowlesi ( P. knowlesi).Methods Histopathological examination of 3 monkeys who died of P. knowlesi infection, 2 P. knowlesi infected monkeys who died of treatment failure with artesunate suppository and 1 P. knowlesi infected monkey that was cured by piperaquine phosphate (PQP) but died of trauma and necrosis of the fore limb.Results The heart, liver, spleen, lung, kidney, brain, pancreas, parathyriod, pituitary and lymph nodes showed severe pathological changes in 3 monkeys (No. 1, 7 and 12) who died of P. knowlesi infection and 1 infected monkey (No. 72) who died of treatment failure with artesunate suppository. Red blood cells containing rmalarial parasites and pigments were concentrated in the capillaries of these organs. Malarial pigments were deposited in many organs or phagocytized by macrophages in 1 monkey (No. 131 ), it was cured by piperaquine phosphate but died of trauma and necrosis of the fore limb; cellular atrophy and disappearance of pancreatic islets, parathyroid and pituitary cells were also observed. One monkey (No.33) treated with artesunate suppository, showed that blood parasites became negative but recrudesced and pituiary later died from a gavage accident. Its organs showed a significant difference to those of the infected monkeys receiving no treatment. Only the liver Kupffer cells and cerebral matrix contained malarial parasites and pigments; many relevant intemal organs showed repair.Conclusion The pathological changes of relevant internal organs of Macaca mulatta infected with P. knowlesi were examined in detail, especially cellular atrophy and the disappearance of pancreatic islets, parathyoid and pituitary cells and myolysis of cardiac muscles. These changes have not previously been reported elsewhere.
陈林李国桥卢耀增罗灼玲
恶性疟致热原研究现状
2000年
宋建平陈林李国桥
关键词:恶性疟
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