The T-joints of Ti?6Al?4V alloy were manufactured by double-sided synchronized laser beam welding with the homologous filler wire. The formation, microstructure and mechanical properties of welded joints as well as the correlations of each other were investigated. The results indicate that the quality of weld seams is good without defects such as discontinuity, beading, visible cracks or porosity, which is linked to the steady molten pool behavior and droplet transition. The morphologies of the heat affected zone (HAZ) located on the skin and stringer are disparate. The microstructure of the HAZ and fusion zone (FZ) is mainly comprised of acicular martensiticα′ phases. The microhardness of the HAZ and FZ is higher than that of the base metal (BM) and reaches a maximum value at the HAZ near FZ on the stringer. The tensile specimens along the skin and stringer fractured at the BM with ductile fracture surfaces.