Cyclooxygenase is the key enzymes mediating prostaglandings release. In recent years, two isoforms of cyclooxygenase, a constitutive cyclooxygenase(COX-1)and an inducible cyclooxygenase (COX-2),have been identified, from which people have known more about gastrointestinal pathophysiology. This article is a review of COX-1 and COX-2 on the distribution, inducement and regulation in gastrointestinal tract and its relation to programmed cell death, tumor, ulcer and Crohn’s disease.
目的研究乳宁口服液对大鼠乳腺增生的治疗作用。方法建立乳腺增生大鼠模型,灌胃给药乳宁口服液,观察低、中、高剂量[0.5,2.5,5.0 m L/(kg·d)]组大鼠的行为学改变、乳房情况,以及血液中激素水平的变化。结果低、中、高剂量乳宁口服液均能显著改善乳腺增生大鼠模型行为学异常、乳房情况,以及血液中雌二醇(E2)、孕酮(P)、催乳素(PRL)水平(P<0.01),且呈一定的量效关系。结论乳宁口服液对乳腺增生有一定治疗作用。
Objective: To investigate the anti-inflammation and analgesic effects of Quyuningtong paster (QYNTP). Method : Animal models of acute and subacute inflammations including ear edema caused by xylene , capillary permeability increase by acetic acid in mice and plantar edema by albumen, granuloma by cotton ball in rats were made to observe the anti-inflammation effects of QYNTP . Animal models of pain including reaction of body torsion caused by acetic acid and irritations by heat plate in mice were adopted to study the analgesic action of QYNTP. Result: QYNTP could not only significantly inhibit the ear edema, depress the increase of capillary permeability in mice, but relieve the plantar edema and inhibit the granuloma in rats. In addition, it also remarkably reduce the frequency of body torsion reaction,prolong the latent period of the pain reactions and raise the pain threshold in mice. Conclusion : QYNTP has obvious anti-inflammation and analgesic effects.
