To improve spectral X-ray CT reconstructed image quality, the energy-weighted reconstructed image xbins^W and the separable paraboloidal surrogates（SPS） algorithm are proposed for the prior image constrained compressed sensing（PICCS）-based spectral X-ray CT image reconstruction. The PICCS-based image reconstruction takes advantage of the compressed sensing theory, a prior image and an optimization algorithm to improve the image quality of CT reconstructions.To evaluate the performance of the proposed method, three optimization algorithms and three prior images are employed and compared in terms of reconstruction accuracy and noise characteristics of the reconstructed images in each energy bin.The experimental simulation results show that the image xbins^W is the best as the prior image in general with respect to the three optimization algorithms; and the SPS algorithm offers the best performance for the simulated phantom with respect to the three prior images. Compared with filtered back-projection（FBP）, the PICCS via the SPS algorithm and xbins^W as the prior image can offer the noise reduction in the reconstructed images up to 80. 46%, 82. 51%, 88. 08% in each energy bin,respectively. M eanwhile, the root-mean-squared error in each energy bin is decreased by 15. 02%, 18. 15%, 34. 11% and the correlation coefficient is increased by 9. 98%, 11. 38%,15. 94%, respectively.
针对坐落于意大利帕维亚大学的TRIGA Mark Ⅱ反应堆热柱结构进行优化设计,从而满足面向硼中子俘获治疗(BNCT)的单光子发射计算机断层成像(SPECT)研究要求。为提高计算效率并减小统计误差,对比分析使用SSW/SSR方法与直接使用反应堆为源项时热柱内照射位置处中子能谱,其结果基本一致,从而验证了SSW/SSR方法的可靠性。为在该反应堆开展BNCT中SPECT实验,热柱中子束需准直为笔形束。对比分析四种热柱优化方案下束流口处及探测器处热中子和光子通量:40cm长石墨(射束口5cm×3cm);0.5cm厚硼包裹40cm长石墨(射束口5cm×3cm);30cm长天然锂聚乙烯(射束口直径4cm);30cm长天然锂聚乙烯(20cm长射束口直径5cm,5cm长射束口直径4cm,5cm长射束口直径2cm)。结果显示,射束口处热中子通量分别为1.05×108,2.52×107,6.08×107和5.10×107#/(cm2·s)。综合考虑中子准直效果及光子污染,方案三具有最优性能。为后续进行BNCT-SPECT理论和实验研究提供了基础,从而有效促进BNCT剂量准确评估方法的研究进程。
