国家自然科学基金(81100829)
- 作品数：1 被引量：3H指数：1
- 相关作者：杨过沈钰琳黄莉萍梁尚栋熊伟更多>>
- 相关机构：南昌大学附属口腔医院南昌大学更多>>
- 发文基金：国家自然科学基金更多>>
- 相关领域：医药卫生更多>>
- Effect of emodin on neuropathic pain transmission mediated by P2X3 receptor and CGRP of tri-geminal ganglion
- The present research investigated the effect of emodin on trigeminal neuralgia mediated by P2X3 receptor and C...
- 熊伟吴琴黄莉萍高云梁尚栋
- 关键词：CGRPEMODIN
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- Effect of intermedin(IMD) and its receptor of dorsal root ganglia(DRG) on chronic neuropathic pain of chronic constriction injury(CCI) rats
- Objective To investigate the effect of intermedin(IMD) and its receptor of dorsal root ganglia on chronic neur...
- Shuyi QIUYun GAOYun YIQin WUShangdong LIANG
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- Effect of mlncRNA2Y on the expression of P2X_3 receptor in primary cultured dorsal root ganglion neurons
- Objective P2X_3 receptor was related to the transmission of nociceptive information.The expression of mlncRNAs...
- Chaoran ZhengShicheng YuShuangmei LiuHaiying PengShangdong LiangGuilin Li
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- Effect of mlnc RNA2Y on the neuropathic pain mediated by P2X3 receptor in dorsal root gangli-on
- Objective:Neuropathic pain is an intractable disease.Its pathogenesis is associated with the abnormalities of ...
- Huaide JiangChaoran ZhengShangdong LiangGuilin Li
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- 川芎嗪对慢性压迫性损伤眶下神经致大鼠三叉神经痛的作用被引量：3
- 2017年
- 三叉神经痛(trigeminal neuralgia,TN)是局限于三叉神经1支或多支分布区域的反复发作的短暂剧烈疼痛,临床发病率高,严重影响患者生活质量,难以完全治愈。本研究旨在探讨川芎嗪(tetramethylpyrazine,TMP)对慢性压迫性损伤眶下神经(chronic constriction injury of the infraorbital nerve,ION-CCI)致大鼠TN的影响。Sprague-Dawley大鼠随机分为4组:假手术组(sham)、假手术+川芎嗪组(sham+TMP)、模型组(TN)、模型+川芎嗪组(TN+TMP)。通过ION-CCI建立大鼠TN模型,术后2周每天一次腹腔注射川芎嗪(50 mg/kg)。应用电子测痛仪观察各组大鼠机械痛敏阈值的变化。同时采用RT-PCR、蛋白印迹、免疫组织化学染色等方法检测大鼠术侧三叉神经节(trigeminal ganglia,TGs)中降钙素基因相关肽(calcitonin gene-related peptide,CGRP)的表达变化。术后15天内,TN组大鼠手术侧眶下神经面部感觉区域的机械痛敏阈值和sham组相比明显降低,术后第9天到第15天,TN+TMP组和TN组相比较阈值出现明显升高(P<0.05)。术后第15天,RT-PCR、蛋白印迹、免疫组织化学染色结果表明,与sham组相比,TN组大鼠TGs中CGRP表达明显升高(P<0.05);与TN组相比,TN+TMP组大鼠TGs中CGRP表达显著降低(P<0.05)。以上结果表明,TGs中的CGRP对TN的痛觉传递有着重要作用,TMP对TN有一定的抑制作用,其机制可能和抑制TGs中CGRP表达有关。
- 谭梦霞熊伟何柃锟杨过黄莉萍沈钰琳梁尚栋高云
- 关键词：降钙素基因相关肽三叉神经痛川芎嗪三叉神经节
- The role of P2X7 receptor of superior cervical ganglia in sympathoexcitatory reflex
- Objective Myocardial ischemic injury activates cardiac sympathetic afferent fibers and elicits a sympathoexcit...
- Shuang-Mei LIUChang-Shui XUGui-Lin LIYun GAOBo FANQi-Cheng ZHUShi-Cheng YUChao-Ran ZHENGBing WULi-Chao PENGMiao-Miao SONGQin WUShang-Dong LIANG
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