This paper reports on the dynamic response of highway subgmde under moving heavy Wuck in cold regions. Numerical simulations are performed in two stages. In the first stage, the moving heavy truck vibration, induced by mad roughness, is calculated through a three-dimensional dynamic interaction model of heavy tmckavement-subgrade, and the lime-histories of nodal loads on the top of the base are calculated through this model. In the second stage, a two-dimensional dynamic finite element model of the bgrade-ground system is formulated, using the calculated nodal loads from the first stage as input. The dynamic resporkse of the subgrade is validated by field measurements, and the effects of mack type, axle loading, running speed, and road roughness on the vertical dynamic slress in the unfrozen period and the spring thawing period are analyzed and discussed.