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国家自然科学基金(10872121)

作品数:15 被引量:8H指数:2
相关作者:张能辉谭邹卿孟玮烈李晶晶谭邹卿更多>>
相关机构:上海大学上海市应用数学和力学研究所上海市力学在能源工程中的应用重点实验室更多>>
发文基金:国家自然科学基金上海市教育委员会重点学科基金上海市教育委员会创新基金更多>>
相关领域:医药卫生理学自动化与计算机技术生物学更多>>

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15 条 记 录,以下是 1-10
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变截面耦合微悬臂双梁的基本振动特性
2019年
本文研究了连接部件的几何参数对变截面耦合微悬臂双梁振动特性的影响.首先,利用集总参数法建立了等效的两自由度系统耦合振动的解析模型;其次,利用分离变量法获得了耦合双梁自由振动的固有频率、振幅比和强迫振动的反共振频率;最后,通过比对解析解、有限元数值结果和实验数据,验证了解析预测的可靠性.研究结果表明,连接部件的宽度和初始偏转角的变化会对耦合双梁振动的特性产生较大的影响.
张颖吴君正张能辉
关键词:固有频率振幅比反共振频率集总参数法
双链DNA生物膜弹性模量的蒙特卡罗模拟被引量:2
2014年
目的 研究吸附于微悬臂梁基底上双链DNA生物膜的弹性模量.方法 采用基于中观连续介质液晶理论的Parsegian经验势,描述粗粒化DNA圆柱之间相互作用能;采用蒙特卡罗法模拟加载前后DNA链的微观分布模式;采用思想实验法和宏观连续介质压缩弹性杆模型,预测DNA生物膜弹性模量.结果 双链DNA生物膜的弹性模量约为0.1 ~80 MPa.结论 对比随机分布模式,经典的六角形均匀分布假设低估了DNA生物膜的弹性模量;封装密度的增加和缓冲盐溶液浓度的减小均有助于提高DNA生物膜弹性模量.这些结果对进一步认识临床工作中相关DNA生物膜的力学性质及其调控规律具有重要意义.
汤恒松孟玮烈谭邹卿张能辉
关键词:双链DNA生物膜弹性模量蒙特卡罗法
Multiscale tensegrity model for the tensile properties of DNA nanotubes
2023年
DNA nanotubes(DNTs)with user-defined shapes and functionalities have potential applications in many fields.So far,compared with numerous experimental studies,there have been only a handful of models on the mechanical properties of such DNTs.This paper aims at presenting a multiscale model to quantify the correlations among the pre-tension states,tensile properties,encapsulation structures of DNTs,and the surrounding factors.First,by combining a statistical worm-like-chain(WLC)model of single DNA deformation and Parsegian's mesoscopic model of DNA liquid crystal free energy,a multiscale tensegrity model is established,and the pre-tension state of DNTs is characterized theoretically for the first time.Then,by using the minimum potential energy principle,the force-extension curve and tensile rigidity of pre-tension DNTs are predicted.Finally,the effects of the encapsulation structure and surrounding factors on the tensile properties of DNTs are studied.The predictions for the tensile behaviors of DNTs can not only reproduce the existing experimental results,but also reveal that the competition of DNA intrachain and interchain interactions in the encapsulation structures determines the pre-tension states of DNTs and their tensile properties.The changes in the pre-tension states and environmental factors make the monotonic or non-monotonic changes in the tensile properties of DNTs under longitudinal loads.
Hanlin LIUNenghui ZHANGWei LU
DNA纳米管力学性能的研究
以DNA自组装技术中的材料基元DNA纳米管为研究对象,本文研究了DNA纳米管的初始封装状态、弹性刚度以及盐溶液浓度、温度等因素对其力学性质的影响。有关方法、模型和结论不仅丰富了软物质力学的理论框架,又为DNA纳米结构的设...
卢伟
关键词:力学性能
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Thickness dependence of viscoelastic stress relaxation of laminated microbeams due to mismatch strain
2022年
Time-dependent behaviors due to various mismatch strains are very important to the reliability of micro-/nano-devices.This paper aims at presenting an analytical model to study the viscoelastic stress relaxation of the laminated microbeam caused by mismatch strain.Firstly,Zhang’s two-variable method is used to establish a mechanical model for predicting the quasi-static stress relaxation of the laminated microbeam.Secondly,the related analytical solutions are obtained by combining the differential method and the eigenvalue method in the temporal domain.Finally,the influence of the substrateto-film thickness/modulus ratio on the relaxation responses of the laminated microbeam subject to a step load of the mismatch strain is studied.The results show that the present predictions are consistent with the previous theoretical studies.Furthermore,the thickness dependence of stress relaxation time of the laminated microbeam is jointly determined by the intrinsic structural evolution factors and tension-bending coupling state;the stress relaxation time can be controlled by adjusting the substrate-to-film thickness/modulus ratio.
Xiaosheng CAINenghui ZHANGHanlin LIU
重力对DNA-微悬臂梁纳米挠度响应的影响
<正>致力于建立考虑重力因素的微悬臂梁的数学模型,研究了重力对微梁纳米挠度响应的影响。首先,利用Zhang的两变量层合梁模型,求解出梁的正应力、切应力和层间挤压应力;其次,在薄膜层对基底挤压应力、切应力以及自重因素作用下...
孟玮烈陈建中陈皓张能辉
关键词:微悬臂梁
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生物分子粘弹性性质对AFM检测中微梁纳米力学行为的影响
细胞的力学性能与人体的健康密切相关,是细胞病变或癌细胞转移的重要指标。AFM以其精准的操作、适用于生理条件和皮牛级的分辨率等特点已成为测量细胞力学性能的常用工具之一,其中力夹支模式被认为是一种极具潜力的检测细胞粘弹性的手...
吕强张能辉
关键词:生物分子粘弹性AFM复模态法微分求积法
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Clamped-end effect on static detection signals of DNA-microcantilever被引量:1
2021年
Boundary constraint induced inhomogeneous effects are important for mechanical responses of nano/micro-devices.For microcantilever sensors,the clamped-end constraint induced inhomogeneous effect of static deformation,so called the clamped-end effect,has great influence on the detection signals.This paper is devoted to developing an alternative mechanical model to characterize the clamped-end effect on the static detection signals of the DNA-microcantilever.Different from the previous concentrated load models,the DNA adsorption is taken as an equivalent uniformly distributed tangential load on the substrate upper surface,which exactly satisfies the zero force boundary condition at the free-end.Thereout,a variable coefficient differential governing equation describing the non-uniform deformation of the DNA-microcantilever induced by the clamped-end constraint is established by using the principle of minimum potential energy.By reducing the order of the governing equation,the analytical solutions of the curvature distribution and static bending deflection are obtained.By comparing with the previous approximate surface stress models,the clamped-end effect on the static deflection signals is discussed,and the importance of the neutral axis shift effect is also illustrated for the asymmetric laminated microcantilever.
Junzheng WUNenghui ZHANG
生物芯片技术与力学被引量:1
2022年
生物芯片是在固相基底上集成了大量生物分子的微型化、集成化的检测和处理平台,在与生物相关的许多领域均有重大应用。文章主要介绍了生物芯片的发展历史、技术支撑、主要操作步骤和存在的困难,着重分析了生物芯片技术存在的若干关键力学问题,并对未来发展方向进行了初步展望。
王首智张能辉任九生
关键词:生物芯片
DNA吸附膜热膨胀系数对环境条件的依赖性被引量:1
2021年
目的研究基底上DNA吸附膜热膨胀系数对环境条件的依赖性。方法将DNA吸附分子视为有预应变的宏观连续介质薄膜,建立了DNA膜-基底等效层合梁模型,预测温度载荷作用下DNA-微悬臂梁挠度;采用Parsegian经验势描述DNA吸附膜的介观自由能,利用DNA液晶-基底多尺度挠度模型、思想实验法和等效变形法,建立DNA吸附膜微观结构与其宏观力学性能的跨尺度关系,预测基底上DNA吸附膜的热膨胀系数。结果在给定离子强度条件下,双链DNA吸附膜的热膨胀系数为(0.3~8.05)×10^(-4)/K,单链DNA吸附膜的热膨胀系数为(1.28~9.33)×10^(-4)/K。结论在微观作用竞争中起主导作用的构型熵变化决定了DNA吸附膜热膨胀系数对环境条件的依赖性;随着温度或离子浓度或DNA种植密度的增加,DNA膜热膨胀系数减小。研究结果对于基因检测及其调控具有指导意义,并为组织工程中组织器官的性能评估提供参考。
吴春霞张乘胤谭邹卿张能辉
关键词:热膨胀系数
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