Mesoporous MCM-41 supported Schiff base and Cu SO4· 5H2 O shows high catalytic activity in the cyclocondensation of mercaptoacetic acid with imines（or aldehydes and amines） to afford pharmaceutically important thiazolidinone derivatives. The catalytic reactions involving twocomponents or three-components afforded the desired product in high yields（up to 98% and 99%）.Moreover, the catalyst works well with respect to recyclability, giving the product in 85% and 83% yields after recycling six times.
