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广西壮族自治区自然科学基金(2002)

作品数:5 被引量:38H指数:3
相关作者:黄巨恩王慧杰覃亚勤黄重敏覃雪英更多>>
相关机构:广西医科大学右江民族医学院附属医院更多>>
发文基金:广西壮族自治区自然科学基金更多>>
相关领域:医药卫生更多>>

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成纤维细胞生长因子对组织损伤保护作用研究的方法学被引量:2
2006年
成纤维细胞生长因子(FGF)是一类在体内广泛分布的生长因子,对中胚层和神经外胚层来源的组织细胞普遍具有促有丝分裂和损伤保护作用,可促进细胞的分裂、增殖和分化,并对多种组织损伤具有修复作用。本文旨在总结FGF对组织损伤保护作用研究中已用过的或可借鉴的实验方法。
黄荣师黄巨恩
关键词:成纤维细胞生长因子
酸性成纤维细胞生长因子的基础与应用研究被引量:20
2005年
原型aFGF是由154个氨基酸残基组成的相对分子质量是16.5×103的小蛋白质分子,等电点5~7,呈酸性,改构体aFGF(MaFGF)则是改变aFGF的结构,即切除1~25位的残基,保留26和27位但替换为蛋氨酸。原型aFGF具有两大类型的活性:其一,促有丝分裂活性,可促进组织细胞分裂、增殖;其二,非促有丝分裂活性,包括舒张血管、神经保护、心肌保护和局部缺血保护等。本文就aFGF的结构及其受体、生物学活性及应用基础研究、可能存在的负面效应以及MaFGF的特性等进行宗述。
王慧杰黄巨恩
关键词:AFGF细胞因子神经营养作用
YMDD mutations in patients with chronic hepatitis B untreated with antiviral medicines被引量:10
2005年
AIM: To polymerase P region (YMDD) mutations of hepatitis B virus gene (HBV DNA) in patients with chronic hepatitis B (CHB) untreated with antiviral medicines and to explore its correlation with pre-c-zone mutations, HBV genotypes and HBV DNA level, and to observe its curative effect.METHODS: A total of 104 cases (38 cases in group of familial aggregation and 66 cases in group of non-familial aggregation) were randomly chosen from 226 patients with CHB who did not receive the treatment of lamivudine (LAM)and any other antivirus drugs within the last one year.Their serum YMDD mutations were detected by microcosmic nucleic acid and cross-nucleic acid quantitative determination,HBV genotypes by PCR-microcosmic nucleic acid crossELISA, HBV DNA quantitative determination and fluorescence ration PCR analysis, hepatitis B virus markers (HBVM) by ELISA. LAM was taken by 10 patients with YMDD mutations and its curative effect was observed.RESULTS: Twenty-eight cases (26.9%) had YMDD mutations, of them 11 cases (28.9%) were in familial aggregation group (38 cases) and 17 cases (25.8%) in nonfamilial aggregation group (66 cases) with no significant difference between the two groups. Twenty-seven point one percent (16/59) cases were positive for HBeAg YMDD mutations, and 26.7% (12/45) cases were negative for HBeAg and positive for anti-HBe. There was also no significant difference between the two groups. Different YMDD incidence rate existed in different HBV genotypes.HBV DNA level did not have a positive correlation with the incidence of YMDD mutations. LAM was effective for all patients with mutations.CONCLUSION: Wild mutant strains in HBV and their incidence rate have no significant difference between familial aggregation and non-familial aggregation. It may have no significant relationship between YMDD mutations and pre-c-zone mutations. HBV DNA level may not have a positive correlation with YMDD mutations. LAM is clinically effective for CHB patients with YMDD mutations.
Zhong-MinHuang Qi-WenHuang Ya-QinQin Yan-ZhuanHe Hou-JiQin Yiao-NanZhou XiangXu Mei-JinHuang
关键词:GENOTYPESLAMIVUDINE
广西百色地区壮族人群乙型肝炎病毒基因型分布初步调查被引量:3
2003年
黄重敏覃亚勤覃后继何延专卢东覃雪英
关键词:壮族乙型肝炎病毒基因型
Clinical characteristics and distribution of hepatitis B virus genotypes in Guangxi Zhuang population被引量:3
2005年
AIM: To investigate the distribution of HBV genotypes and their YMDD mutations in Guangxi Zhuang population, China, and to study the relationship between HBV genotypes and clinical types of HB, ALT, HBV DNA, HBe system as well as the curative effect of Lamivudine (LAM) on hepatitis B.METHODS: A total of 156 cases were randomly chosen as study subjects from 317 patients with chronic hepatitis B (CHB). HBV genotypes were determined by PCR-microcosmic nucleic acid cross-ELISA. YMDD mutations were detected by microcosmic nucleic acid cross-nucleic acid quantitative determination. HBV DNA was detected by fluorescence ratio PCR analysis.LAM was given to 81 cases and its curative effect was observed by measuring ALT, HBV DNA load, HBeAg, and HBeAg/HBeAb conversion rate.RESULTS: HBV genotypes B, C, D, and non-classified genotypes were found in Guangxi Zhuang population.accounting for 25.6%, 47.4%, 58.3%, and 16.0%,respectively. Seventy-four cases were CD-, CB-, BD-mixed genotypes (47.7%). Forty-six (29.5%) cases had YMDD mutations. Genotype B was mostly found in mild and moderate CHB patients. Genotypes C, D and mixed genotype mostly occurred in severe CHB cases.Genotypes D and CD HBV-infected patients had higher ALT and HBV DNA than patients with other types of HBV infection. There was no significant difference among the genotypes in YMDD mutations, clinical types, ALT and HBV DNA level. Non-classified types geno had a significantly lower positive rate of HBeAg than other genotypes (x2= 12.841, P<0.05). There was no significant difference in ALT recovery rate, HBV DNA load, HBeAg,and HBeAg/HBeAb conversion rate, 48 wk after LAM treatment between groups of genotypes D, CD, and nonclassified type.CONCLUSION: Genotypes B, C, and D, non-classified and mixed genotype of HBV are identified in the Guangxi Zhuang population. Variations in genotypes are associated with clinical severity and serum ALT levels, but not with YMDD mutation or HBV DNA load.Therapeutic effects of LAM on clinical parameters are not influenced by diffe
Zhong-Min Huang Qi-Wen Huang Ya-Qin Qin Chun-He Huang Hou-Ji Qin Yiao-Nan Zhou Xiang Xu Chun-Lei Lu
关键词:GENOTYPELAMIVUDINE
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