Thioredoxin is a redox protein while adiponectin is an adipokine. Their relationship has been less appreciated. Here we show that in serum of patients with acute exacerbations of chronic obstructive Pulmonary Disease,decreased activity of thioredoxin coexists with increased level of adiponectin as partial pressure of arterial oxygen decreases. From the results with adiponectin-knockout mice and in vitro experiments, we have found a reciprocal inhibitory relationship, by which adiponectin inhibits cytosolic thioredoxin(Trx1) expression, whereas serum Trx1 influences adiponectin multimerization. The association between extracellular Trx1 and adiponectin attenuates their functions. This relationship is dynamic, and correlated with a body's physiological conditions.
Coronary artery disease(CAD)is one of the major death causes worldwide.Therapeutic methods may improve the progress of CAD.Thus,specific biomarkers are required for detecting coronary stenosis severity and monitoring therapy.Although spiral computed tomography(CT)angiography or coronary angiography may accurate detect coronary stenosis,the both techniques
Thioredoxin is a redox protein while adiponectin is an adipokine. Their relationship has been less appreci- ated. Here we show that in serum of patients with acute exacerbations of chronic obstructive Pulmonary Disease, decreased activity of thioredoxin coexists with increased level of adiponectin as partial pressure of arterial oxygen decreases. From the results with adiponectin-knockout mice and in vitro experiments, we have found a reciprocal inhibitory relationship, by which adiponectin inhibits cytosolic thioredoxin （Trxl） expression, whereas serum Trxl influences adiponectin multimerization. The associa- tion between extracellular Trxl and adiponectin attenuates their functions. This relationship is dynamic, and correlated with a body＇s physiological conditions.
