This paper proposes the corrected likelihood ratio test (LRT) and large-dimensional trace criterion to test the independence of two large sets of multivariate variables of dimensions P1 and P2 when the dimensions P = P1 + P2 and the sample size n tend to infinity simultaneously and proportionally. Both theoretical and simulation results demonstrate that the traditional X2 approximation of the LRT performs poorly when the dimension p is large relative to the sample size n, while the corrected LRT and large-dimensional trace criterion behave well when the dimension is either small or large relative to the sample size. Moreover, the trace criterion can be used in the case of p 〉 n, while the corrected LRT is unfeasible due to the loss of definition.