[Objective] This study aimed to investigate the fluorosis content in the groundwater of Songnen Plain and provide a theoretical basis for the prevention and control of endemic fluorosis in Songnen Plain. [Method] The relationship of drinking water type endemic fluorosis with the fluoride content in the soil and groundwater of Songnen Plain was analyzed. [Result] The endemic disease in this region is concentrated in the Song-Liao Plain and Hulunbuir Plateau on both sides of the Daxinganling Mountain. Severe and medium disease areas are distributed mainly in alluviallacustrine plains with dense depressions of lakes and marshes. The strata are commonly fine-grained loess and mucky soil. The groundwater is dominated by HCO3-Ca·Na and HCO3·Cl-Na·Ca types, with fluorine content of 1.80-16.00 mg/L, generally 4-6 mg/L. Light disease and non-disease areas are distributed in the alluvial-lacustrine plains with less or without depressions of lakes and marshes. The strata are mainly coarse-grained silty soil and sandy soil. The chemical types of ground water are Cl-Ca·Na and HCO 3 Cl-Na·Ca. The content of fluorine in ground water is commonly lower than 2 mg/L. [Conclusion] High fluorine groundwater formation is closely related to the geological environment.