Background Many studies have shown that continuous renal replacement therapy （CRRT） could clean lactate and treat the hyper-lactatemia.On the contrary,some other studies found that filter lactate clearance only accounted for a very small part of total lactate clearance and the hemofilter＇s contribution to the overall lactate clearance was negligible.The objective of this study was to evaluate the effects of various doses of continuous veno-venous hemofiltration （CWH） on plasma lactate elimination in critically ill patients.Methods Patients were divided into three groups according to their incipient plasma lactate concentration.Group A：lactate≤2 mmol/L,group B：lactate 2-5 mmol/L,group C：lactate ≥5 mmol/L.Three different doses （20 ml.kg-1.h-1,35ml·kg-1·h-1 and 45 ml.kg1.h-1） of CWH were applied to critically ill patients who experiencing CWH.The concentrations of plasma lactate in pre-（A）,post-dialyzer （V） sites and ultrafiltrate were measured after each dosage of CWH was carried out for 30 minutes.Rate of lactate clearance by the filter （RLC） and filter lactate clearance （FLC） and Lactate-Sieving Coefficient （LSC） were calculated under different circumstances,including different doses of CWH and different incipient lactate levels.Results Fifteen patients were enrolled and 104 blood samples were drawn and lactate concentrations were measured in this study.RLC was found increased （（9.36±9.73） mmol/h,（13.92±12.56） mmol/h and （16.52±12.71） mmol/h,P ＜0.05respectively） with the dose of CWH increased.RLC was also increased （（3.46±1.46）,（10.38±5.50） and （24.53±14.69） mmol/h,P ＜0.05 respectively） with the incipient lactate increased.FLC was increased （（1.95±0.63）,（2.95±0.74） and （3.45±0.54） L/h,P ＜0.05 respectively） with the dose of CVVH increased.There was no significant difference of LSC in different doses of CWH and different incipient lactate levels.Conclusions Plasma lactate can be eliminated by CWH and differe
Liu Yongjun Ouyang Bin Chen Juan Chen Minying Ma Jie Wu Jianfeng Huang Shunwei Li Lifen Liu Zimeng Guan Xiangdong
