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国家自然科学基金(39970284)

作品数:5 被引量:33H指数:3
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卵泡生长、分化和闭锁的调控被引量:20
2003年
研究卵泡生长启动和分化对于了解雌性生殖机制至关重要。哺乳动物卵细胞在胚胎发育过程中已经形成,并且在生殖峭每个卵原细胞都与若干原始卵泡细胞组合分化成一个原始卵泡。出生后原始卵泡数不再增加。原始卵泡生长启动的分子机制至今还不清楚。相关研究的最新进展表明:(i)原始卵泡的生长启动可能主要受卵泡内外产生的生长因子、激活素和孤儿受体等调节,而可能不受FSH调节;(ii)在颗粒细胞上一旦分化出现FSH受体,FSH即与雌激素以及激活素/抑制素、卵泡抑素一起成为决定卵泡分化倾向的主要因素;(iii)卵泡闭锁可起始于颗粒细胞或卵母细胞凋亡两种形式,卵母细胞中组织型纤溶酶激活因子(tPA)蛋白活性的提前表达将引发卵母细胞凋亡。
金萱刘以训
关键词:原始卵泡卵母细胞颗粒细胞卵泡生长
Follicular growth,differentiation and atresia被引量:4
2003年
Only limited numbers of primordial follicles in mammalian ovary grow and differentiate to reach the stage of dominate follicles and ovulate. 99% of the follicles in the ovary undergo atresia at various stages of development. Regulation of follicular growth, development and atresia is a complex process and involves interactions between endocrine factors and intraovarian regulators. This review summa-rized:ⅰ) FSH may not be a survival factor in regulating slow-growing preantral follicles. Some locally produced growth factors, activin and orphan receptors might play a more important role at this stage. ⅱ) Estrogen, activin/ inhibin and follistatin coordinate with FSH to regulate and control follicle differentiation. ⅲ) There are two types of follicular atresia induced by apoptosis which originates from GC or oocyte, respectively. Early translation of tPA mRNA into tPA protein in oocyte may be associated with oocyte apoptosis.
JIN Xuan & LIU Yixun State Key Laboratory of Reproductive Biololgy, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China
关键词:哺乳动物原始卵泡卵泡生长细胞分化
Endometrium implantation and ectopic pregnancy
2004年
Embryo in uterine implantation is a complex and multifactor-related process and is a downstream and ideal point for woman fertility control. Understanding the cellular and molecular mechanism of implantation is a prerequisite for development of anti-implantation contraceptives. In spite of considerable accumulation of information from the laboratory animals that has been achieved, it is difficult to generate such information in human due to ethical restriction and experimental limitation, and the present knowledge for understanding the definitive mechanisms which control these events remains elusive. Embryo implantation can also occur outside uterus. Some women with abdominal pregnancies could successfully complete the processes of gestation and bear normal babies, implying that implantation itself may be not an endometrium-specific process. Reproductive biologists should cooperate with gynecologists to further comparatively study the molecular and cellular mechanisms of implantation normally occurring in endometrium and abnormally appearing outside uterine cavity. Such collaborative studies may generate new important information for developing anti-implantation contraceptive and for techniques of accurate diagnosis of ectopic pregnancy. A specially designed GnRH-2 analog and a combination use of low dose RU486 and gossypol as anti-implantation contraceptives have been suggested. Keywords embryo implantation - implantation window - materno-embryonic dialogue - ectopic pregnancy
LIU Yixun
关键词:EMBRYO
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