In this study,in vitro degradation and biocompatibility of Mg-Nd-Zn-Zr(NZK) alloy were investigated to determine its suitability as a degradable medical biomaterial.Its corrosion properties were evaluated by static immersion test,electrochemical corrosion test,scanning electron microscopy(SEM),and energy dispersive spectroscopic(EDS) analysis,and in vitro biocompatibilities were assessed by hemolysis and cytotoxicity tests.Pure magnesium was used as control.The results of static immersion test and electrochemical corrosion test in simulated body fluid(SBF) demonstrated that the addition of alloying elements could improve the corrosion resistance.The hemolysis test found that the hemolysis rate of calcium phosphate coated NZK alloy was 4.8%,which was lower than the safe value of 5%.The cytotoxicity test indicated that NZK alloy extracts did not significantly reduce MC3T3-E1 cell viability.Hemolysis test and cytotoxicity test display excellent hemocompatibility and cytocompatibility of NZK alloy in vitro.Our data indicate that NZK alloy has excellent biocompatibility and thus can be considered as a potential degradable medical biomaterial for orthopedic applications.
WANG YongPingHE YaoHuaZHU ZhaoJinJIANG YaoZHANG JianNIU JiaLinMAO LinYUAN GuangYin
In this study, in vitro blood biocompatibility of Mg-Nd-Zn-Zr (JDBM) alloy was investigated to determine its suitability as a degradable medical biomaterial. Blood biocompatibility was assessed by blood cell aggregation, platelet adhesion, and protein adsorption. A titanium alloy was used as control. The results showed that the JDBM alloy did not induce significant blood cell aggregation, platelet adhesion, and protein adsorption comparison with the titanium alloy (P>0.05). Our data indicate that the JDBM alloy has excellent in vitro blood compatibility, and thus can be considered as a potential degradable biomaterial for medical applications with respect to hemocompatibility.
WANG YongPingOUYANG YuanMingHE YaoHuaCHEN DaoYunJIANG YaoMAO LinNIU JiaLinZHANG JianYUAN GuangYin
