Objective:This paper discusses the composition of prescription qualitative,quantitative design principles and methods based on herbal property combination,describing the method application in new prescription design.Method:Qualitative property-combination pattern(PP)calculation was based on bipartite graphing and performing a greedy algorithm which was designed to optimize obtaining a new herbal prescription.Quantitative PP calculation was based on the qualitative computation.To calculate the Euclidean distance for the PP of the new prescription,an optimized algorithm for solving the unknown minimum Euclidean distance was used with,the new weighted proportions.Finally,non-linear optimization software was used to find the minimum Euclidean distance.Results:Using the PP of classic prescription Large Yin-Nourishing Pill,applying quantitative PP calculation a new prescription was created.Mathematical algorithms based on property combinations of traditional Chinese herbs can be applied to identify compatibility and synergies of herbs within prescriptions,especially classic formulas.Conclusion:In silico methods can then be used to create new prescriptions or modify existing ones depending on need.This type of automated approach may increase efficiency in designing new drugs based on Chinese herbs.
Objective:In this study,the property combinations(PCs)of single herbs,two-herb combinations,and multi-herb prescriptions were studied to determine that the propertycombination patterns will be associated with these three levels.Method:By calculating the prescription PC weight,we analyzed the PCs of the single herb coptis rhizome,the two-herb combination of coptis rhizome and scutellaria root,and the classic prescriptions Coptis Decoction to Resolve Toxicity,White Tiger Decoction to Resolve Toxicity,and Peony Decoction,all three of which contain coptis and scutellaria.Results:Calculated results show that cold-bitter-lung,cold-bitter-heart,and cold-bitterstomach are present in both Coptis Decoction and White Tiger Decoction and have the highest PC weights.The weights of coptis and scutellaria in Peony Decoction differs from in their weights in Coptis Decoction and White Tiger Decoction,in that the PCs of highest weights in Peony Decoction are cold-bitter-spleen,cold-bitter-liver,cold-bitter-large intestine,coldsour-liver,and cold-sour-spleen.Conclusion:This novel method for exploring the properties and compatibilities of traditional Chinese herbs helps validate the combination theories of herbs.Application of this method may be valuable in designing new efficacious herbal prescriptions.
