Hannum and colleagues performed DNA methylation sequencing to examine the relationship between DNA methylome and aging rate.Notably,they succeeded in building a quantitative and reproducible model based on the epigenetic bio-markers to predict aging rate with high accuracy.This progress en-lightens us in many aspects particularly in applying this novel set of bio-markers on studying the mech-anism of aging rate using adult tissue-specifi c stem cells,building up a potential quantitative model to explore the mechanism for other epigenetic factors like non-coding RNA,and understanding the princi-ple and mechanism of 3D chromatin structure in epigenetic modulation.
Ming LiWensu LiuTingting YuanRuijun BaiGuang-Hui LiuWeizhou ZhangJing Qu
