To study insulino-mimetic effects of bis（α-furancarboxylato）oxovanadium（IV）（BFOV）,a orally active antidiabetic vanadyl complex,on glucose uptake and lipogenesis in isolated rat adipocytes were determined by using 2-deoxy-D——glucose and D-glucose,respectively.Lipolysis was assayed by free fatty acids（FFA） released from isolated rat adipocytes treated with epinephrine.The results showed that BFOV,similar to insulin,concentration-dependently significantly enhanced the uptake of 2-deoxy-D——glucose and the transformation from D-glucose to lipid in isolated rat adipocytes,with the EC50 values of（0.31±0.08） mmol·L-1 and（0.49±0.12） mmol·L-1,respectively.Moreover,BFOV markedly inhibited FFA release from isolated rat adipocytes treated with epinephrine,and the IC50 value was（0.30±0.20） mmol·L-1.BFOV had insulino-mimetic effects such as enhancing glucose uptake and lipogenesis,as well as inhibiting lipolysis.
