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国家自然科学基金(20271034)

作品数:7 被引量:25H指数:3
相关作者:鲁晓明李丽邓元毛希安王波更多>>
相关机构:首都师范大学中国科学院北京大学更多>>
发文基金:国家自然科学基金北京市自然科学基金更多>>
相关领域:理学医药卫生自动化与计算机技术更多>>

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1,3-丙二胺邻苯二酚钼钨手性八面体配合物的仿生合成、晶体结构以及与ATP作用的液相NMR研究被引量:3
2005年
合成了1,3-丙二胺邻苯二酚钼钨手性八面体配合物(NH3CH2CH2CH2NH2)2[Mo0.4W0.6O2(C6H4O2)2],并对其进行了单晶结构解析,研究了其与ATP作用的液相NMR谱.该晶体属正交晶系,空间群为Pcan.晶胞参数a=0.7501(2)nm,b=2.3994(7)nm,c=1.2178(4)nm,Z=4.[Mo0.4W0.6O2(C6H4O2)2]2-的配位几何构型为手性八面体,晶体为外消旋体.配位阴离子中MoW中心金属离子除了与两个端基O配位形成cis-MO键外,同时还分别与两个邻苯二酚配位基团的的氧原子配位,形成4个M—Ob(M=Mo,W)键,构成两个五元环.利用1HNMR,13CNMR,31PNMR以及1H-15NHMBC对标题配合物及其与ATP在D2O溶剂中的作用进行了研究,发现标题配合物的MoW中心金属离子在纯D2O溶剂中被还原成+5价,但与ATP混合后转化为+6价,且与原配位基邻苯二酚发生解离.解离后的[MO2]2+最大可能与腺嘌呤上的氨基N原子配位,而此配位可能是其抗癌抗肿瘤活性的主要作用机理之一.
鲁晓明邓元李丽姜凌毛希安叶朝辉
关键词:晶体结构ATP
含钼化合物及其配合物的抗癌抗肿瘤活性被引量:15
2005年
钼是生命体所必需的微量元素。本文介绍了钼在人体中的作用,钼缺乏和钼过量对人体的影响,并介绍了含钼化合物以及配合物的抗癌抗肿瘤研究情况。
邓元鲁晓明庞小丽
关键词:钼配合物生理功能钼多酸抗癌药物
钼、钨氧转移酶仿生配合物的EPR和UV-VIS研究被引量:5
2003年
利用儿茶酚的还原性,选择性地将Mo(VI)还原成Mo(V),同时保留W(VI)的电子组态,仿生合成了(NH3CH2CH2NH2)3[Mo(v)O2(OC6H4O)2](1),(NH3CH2CH2NH2)2.5[Mo(v)0.5W(Vl)0.5O2(OC6H4O)2](2)和(NH3CH2CH2NH2)2[W(VI)O2(OC6H4O)2](3)三种配合物,进行了紫外可见光谱(UV—VIS)和电子顺磁共振(EPR)研究,并与鸡肝中黄嘌呤脱氢酶和牛奶中黄嘌呤氧化酶的UV-VIS以及牛奶中黄质氧化酶的EPR进行了比较.
鲁晓明刘顺成毛希安叶朝晖卢景芬
关键词:EPRUV-VIS
EPR and UV-vis studies of biomimetic complexes of molybdoenzyme and tungstoenzyme
2003年
The Mo(Ⅴ) and W(Ⅵ) complexes of (NH3CH2- CH2NH2)3[Mo(Ⅴ)O2(OC6H4O)2] (1), (NH3CH2CH2NH2)2.5 [Mo(Ⅴ) 0.5W(Ⅵ)0.5O2(OC6H4O)2] (2) and (NH3CH2CH2NH2)2- [W(Ⅵ)O2(OC6H4O)2] (3) were synthesized by choosing cate-chol ligand which shows a good reductive property and tak-ing advantage of EMo > EW. Their EPR and UV-vis spectra were compared with the oxidized UV-vis spectra of xanthine dehydrogenase from chicken liver and xanthine oxidase from milk and the EPR spectrum of flavoenzyme from milk.
LU XiaomingLIU ShunchengMAO XiYE ZhaohuiLU Jingfen
关键词:仿生合成电子顺磁共振
The Reaction of Molybdenum with 2,3-Dihydroxynaphthalene被引量:1
2007年
[H2N(CH2)3NH312[MoO2(C10H6O2)2] (1) was synthesized by the 2,3-dihydroxynaphthalene in the mixed solvent of CH3OH, CH3CN reaction of (n-Bu4N)4[Mo8O26] with and 1,3-propanediarnine. (C5HllN2)2- [HeN(CH2)3NH2][MoO2(CloH6O2)2] (2) was obtained by the reaction of Na2MoO4.2H20 with 2,3-dihydroxynaphthalene in the same solvent above. Both of the complexes possess complex anion [Mo(VI)O2(OC10H6O)2]^2- which shows pseudo-octahedrally coordinated fashion, while the counterions are two protonated 1,3-propanediamine in complex 1 and (CsH11N2)^+ in complex 2. (C5H11N2)+ is the byproduct of reaction 2, which results from combination of acetonitrile with 1,3-propanediamine. Packing diagrams of the two complexes are also different. There is anti-parallel-aligned-double-meso-bilayer unit in complex 1. However there are four chiral anions arranged in anticlockwise orientation in complex 2.
鲁晓明裴秀焕王晓军叶朝辉
关键词:ENANTIOMER
(NH_2CH_2CH_2NH_3)_4[W~ⅤO_2(OC_6H_4O)_2]_2(NH_3CH_2CH_2NH_3)·H_2O的合成、晶体结构、EPR以及与同构物的比较被引量:1
2005年
Cis-dioxo-catecholatotungsten(V) complex (NH2CH2CH2NH3)4[WⅤO2(OC6H4O)2]2(NH3CH2CH2NH3)·H2O (1) was synthesized at room temperature by the reaction of tetrabutyl ammonium decatungstate with catechol in the mixed solvent of CH3OH, CH3CN and NH2CH2CH2NH2. The crystal structure of complex was determined by X-ray diffraction structural analysis. The results show that complex belongs to monoclinic system with space group P21 / c, a=0.712 8(3) nm, b=3.082 3(11) nm, c=0.982 8(4) nm, β=102.639(6)°, V=2.106 8(14) nm3, Z=2, R1=0.062 8, wR2=0.183 7. Compared the complex with its analogous complexes (NH2CH2CH2NH3)3[MoⅤO2(OC6H4O)2], it is found that the coordination structure of W have no changes in the processing of electron transfer of tungsten-containing enzymes from the result of the similarity of the EPR spectra of the complexes and flavoenzyme from milk. CCDC: 272937.
鲁晓明宋富根王波李丽
关键词:晶体结构EPR
[(NH_2CH_2CH_2NH_3)_2W^(Ⅵ)O_2(NHC_6H_4NH)_2]_2(NH_2CH_2CH_2NH_2)·H_2O配合物的合成与晶体结构被引量:1
2005年
Cis-dioxo-tungsten(Ⅵ ) complex, (NH2CH2CH2NH2)[(NH2CH2CH2NH3)2WⅥO2(NHC6H4NH)2]2·H2O is synthesized at room temperature by the reaction of sodium tungstate with o-phenylenediamine. The crystal structure of complex was determined by X-ray diffraction structural analysis. The results show that complex belongs to monoclinic system with space group P21 / c, a=0.712 8(2) nm, b=3.081 1(10) nm, c=0.981 9(3) nm, β=102.615(4)°, V=2.104 4(11) nm3, Z=2, μ=55.26 cm-1, F(000)=1 176. Compared the complex with its analogous biomimetic complexes of the cofactor of molybdoenzymes and tungstoenzymses, it is found that the variance of the coordination atoms and the metal ions center have no influence on the coordination feature, and exhibits distored octahedral coordination with cis-dioxo o-phenylenediamine. CCDC: 252834.
鲁晓明宋富根王波李丽
关键词:H2O晶体结构配合物ROOM
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