In this paper,we consider the following system of integral equations on upper half space {u(x) = ∫Rn + (1/|x-y|n-α-1/|-y|n-α) λ1up1(y) + μ1vp2(y) + β1up3(y)vp4(y) dy;v(x) = ∫Rn + (1/|x-y|n-α-1/|-y|n-α)(λ2uq1(y) + μ2vq2(y) + β2uq3(y)vq4(y) dy,where Rn + = {x =(x1,x2,...,xn) ∈ Rn|xn〉 0}, =(x1,x2,...,xn-1,-xn) is the reflection of the point x about the hyperplane xn= 0,0 〈 α 〈 n,λi,μi,βi≥ 0(i = 1,2) are constants,pi≥ 0 and qi≥ 0(i = 1,2,3,4).We prove the nonexistence of positive solutions to the above system with critical and subcritical exponents via moving sphere method.