There exist some controversies over the larger zoogeographic divisions of the arid areas of Central Asia, whose characteristics include complex ecological environments, complex fauna origins and unique patterns of animal distribution. The aim of this study was to determine, using quantitative analysis, the distribution patterns of amphibians and reptiles in the arid areas of Central Asia, whose various physiographical regions were divided into 17 Operative Geographical Units (OGUs). Based on the presence or absence of 52 amphibian and reptile genera in the 17 OGUs, and by making use of the Czekanowski Similarity Index, the Baroni-Urbani and Buser's Similarity Index, and the strong and weak boundary test, we studied the biotic boundaries within these contested regions. In accordance with our results, the classification dendrogram was divided into two main branches. One branch is composed of the northern OGUs of the Altai Mountains which are a part of the Euro-Siberian Subrealm. The other branch includes all of the OGUs south of the Altai Mountains, which belong to the Central Asia Subrealm. There is a significantly weak biotic boundary (DW〉0, GW〉GS, P〈0.01) between the Euro-Siberian Subrealm and the Central Asia Subrealm that corre- sponded to the transitional zones. The boundary between the two subrealms runs along the Altai Mountains, the Sayan Mountains, the Hangai Mountains and the Mongolian Dagurr Mountains. The boundaries between the main branches in the Central Asia Subrealm are weak, reflecting the widespread existence of transitional zones in the arid areas of Central Asia. The Tianshan Mountains should be elevated to form its own separate region, "the Middle Asian Mountain Region", which, due to its special fauna and environment, would be classified at the same level as the Mongolia-Xinjiang Region. With the approach of creating a cluster analysis dendogram based upon the genera of amphibians and reptiles, the relationship of these higher level zoogeographical divisions was successful