＜正＞（R）-l,l,l-trifluoro-2-hydroxy-2-methylpropanamides,represented by AZD7545,were known as pyruvate dehydrogen...
LI,Tian-Wen~1,SHANG,Pei-Hua~1,CHENG,Chang-Mei`(*,1),CHEN,Zhe-Sheng~(*,2),ZHAO,Yu-Fen~1 1 Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology(Ministry of Education),Department of Chemistry,Tsinghua University,Beijing,100084 2 Department of Pharmaceutical Sciences,College of Pharmacy and Allied Health Professions,St. John''s University,New York,NY 11439
An efficient and novel method for synthesizing 3′,5′-dithio-2′-deoxyguanosine was described.In this method normal guanosine was used as the starting material.A very efficient procedure was used to synthesize 2-O-tosylguanosine 1,which used 0.1 eq.DBTO instead of 2 eq.1 was treated with LTBH to give 9-(2-deoxy-β-D-threo-pentofuranosyl)guanine 2.2 could be easily turned to the target compound.
Pei Hua ShangChang Mei ChengHua WangHong Chao ZhengYu Fen Zhao
A series of telbivudine 3′-O-acetyl-5′-O-phenyl-N-alkylphosphramidate derivatives have been synthesized and their structures were confirmed by El-MS, ^1H NMR and ^13C NMR. We evaluated their anti-HBV activity in vitro. Two compounds 6d and 6f, turned out to be more active than telbivudine.
