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国家自然科学基金(21277037)

作品数:3 被引量:9H指数:1
相关作者:赵瑞芳季天骄赵宇亮聂广军王海更多>>
相关机构:国家纳米科学中心清华大学更多>>
发文基金:国家自然科学基金国家重点基础研究发展计划更多>>
相关领域:理学化学工程生物学更多>>

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Nanosurface chemistry and dose govern the bioaccumulation and toxicity of carbon nanotubes, metal nanomaterials and quantum dots in vivo被引量:1
2015年
The chemical and biological mechanisms of life processes mostly consist of multistep and programmed processes at nanoscale levels. Interestingly enough, cell, the basic functional unit and platform that maintains life processes, is composed of various organelles fulfilling sophisticated functions through the precise control on the biomolecules (e.g., proteins, phospholipid, nucleic acid and ions) in a spatial dimension of nanoscale sizes. Thus, understanding of the activities of manufactured nanoscale materials including their interaction with biological sys- tems is of great significance in chemistry, materials sci- ence, life science, medicine, environmental science and toxicology. In this brief review, we summarized the recent advances in nanotoxicological chemistry through the dis- section of pivotal factors (primarily focusing on dose and nanosurface chemistry) in determining nanomaterial- induced biological/toxic responses with particular empha- sis on the nanomaterial bioaccumulation (and interaction organs or target organs) at intact animal level. Due to the volume of manufacture and material application, we deliberately discussed carbon nanotubes, metal/metal oxide nanomaterials and quantum dots, severing as representativematerial types to illustrate the impact of dose and nanosurface chemistry in these toxicological scenarios. Finally, we have also delineated the grand challenges in this field in a conceptual framework of nanotoxicological chemistry. It is noted that this review is a part of our persistent endeavor of building the systematic knowledge framework for toxicological properties of engineered nanomaterials.
赵峰孟幻晏亮汪冰赵宇亮
关键词:BIOACCUMULATION
Biodegradable cationic e-poly-L-lysine-conjugated polymeric nanoparticles as a new effective antibacterial agent
2015年
Biocompatible and biodegradable ε-poly-L- lysine (EPL)/poly (ε-caprolactone) (PCL) copolymer was designed and synthesized. The amphiphilic EPL-PCL copolymer could easily self-assembled into monodispersed nanoparticles (NPs), which showed a broad-spectrum antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus subtilis. Interestingly, the antibacterial efficacy of the novel NPs is more potent than the cationic peptide EPL. To explore the underlying mechanism of the biodegradable cationic NPs, various possible antibacterial pathways have been validated. The NPs have been found that they can disrupt bacterial walls/ membranes and induce the increasing in reactive oxygen species and alkaline phosphatase levels. More importantly, the self-assembled NPs induced the changes in bacterial osmotic pressure, resulting in cell invagination to form holes and cause the leakage of cytoplasm. Taken together, our results suggest that the EPL-PCL NPs can be further developed to be a promising antimicrobial agent to treat infectious diseases as surfactants and emulsifiers to enhance drug encapsulation efficiency and antimicrobial activity.
赵瑞芳王海季天骄Greg Anderson聂广军赵宇亮
一种生物可降解的高效广谱抗菌活性的纳米多肽聚合物被引量:8
2015年
近年研究发现大肠杆菌和金黄色葡萄球菌感染是一系列慢性疾病发生的重要因素。目前临床上使用的大多数杀菌或抑菌的主要机制是通过选择性的作用于细菌细胞核酸和蛋白质合成系统的特定环节,妨碍细菌生命活动。导致细菌死亡.然而,细菌表面形态结构完整性仍然保持,导致细菌耐药性的产生.
赵瑞芳王海季天骄Greg Anderson聂广军赵宇亮
关键词:生物可降解细菌细胞纳米广谱葡萄球菌感染
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