A phytochemical investigation on the aerial parts of Artemisia brachyloba led to the isolation of 13 compounds（1-13） for the first time, including eight lignans（1-8） and five flavonoids（9-13）. The structures of the isolated compounds were elucidated by analysis of the NMR spectroscopic data and comparison with the literature. The 1 H and 13 C NMR data of 1 were fully assigned for the first time by the 2 D NMR analysis. All the isolates were evaluated for their inhibitory effects on nitric oxide production in lipopolysaccharide-challenged BV-2 microglial cells.
Puming ZhangChen ZhangKewu ZengYong JiangPengfei Tu
A phytochemical investigation on the aerial parts of Artemisia giraldii var. longipedunculata led to the isolation of 10 known sesquiterpenes, including 12-hydroxy-α-cyperone（1）, 1β,6α-dihydroxyeudesma-4（15）-ene（2）, carainterol A（3）, oplodiol（4）, douglanin（5）, 1α-hydroxyisodauc-4-en-15-al（6）, 3α,6α-dihydroxybisabola-4,10-diene（7）, 4α,5β-dihydroxybisabola-2,10-diene（8）, opposit-4（15）-ene-1β,7-diol（9）, and saniculamoid D（10）, respectively. Their structures were elucidated by analysis of the MS and NMR spectroscopic data and comparison with the literature. All the isolates were obtained from A. giraldii var. longipedunculata for the first time, and five of them were obtained from the genus Artemisia for the first time. Additionally, the 13 C NMR data of 1 were fully assigned based on the 2 D NMR data for the first time.
Yang XueChen ZhangZhibo WuPuming ZhangMingbo ZhaoYong JiangPengfei Tu
