Let G=(V,E)be a graph,for an element x∈V∪E,the open total neighborhood of x is denoted by N_(t)(x)={y|y is adjacent to x or y is incident with x,y∈V∪E},and Nt[x]=Nt(x)∪{x}is the closed one.A function f:V(G)∪E(G)→{−1,0,1}is said to be a mixed minus domination function(TMDF)of G if∑_(y∈Nt[x])f(y)≥1 holds for all x∈V(G)∪E(G).The mixed minus domination numberγ′_(tm)(G)of G is defined as γ′_(tm)(G)=min{∑x∈V∪E f(x)|f is a TMDF of G.In this paper,we obtain some lower bounds of the mixed minus domination number of G and give the exact values ofγ′_(tm)(G)when G is a cycle or a path.