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电刺激和损毁丘脑中央下核对大鼠福尔马林诱发伤害性行为的影响(英文): 2007年; 本文旨在研究丘脑中央下核(thalamic nucleus submedius,Sm)是否参与持续伤害感受性调制。以自动运动检测系统记录大鼠一侧后爪皮下注射福尔马林诱发的伤害性行为(烦乱反应)为指标,观察电刺激和电解损毁Sm对烦乱反应的效应。结果显示,电刺激(100μA,5min)同侧或对侧Sm明显抑制福尔吗林诱发的第(?)时相的烦乱反应,而刺激Sm外邻近结构(超过0.5 mm)对烦乱反应无明显效应。电解损毁双侧Sm对第一或第二时相的烦乱反应均无影响。结果提示,Sm不仅参与急性时相性伤害感受性调制,也参与持续性伤害感受性调制。本研究为Sm参与下行痛调制提供了新的证据。; 李杨袁斌唐敬师; 关键词：丘脑中央下核持续性痛福尔马林试验

The relationship of serotoninergic terminals and GABAergic neurons in the ventrolateral orbital cortex of the rat:a light and electron microscopic study: Previous studies have indicated that the ventrolateral orbital cortex(VLO) is involved in an endogenous analge...; Fu-Quan HUO~(1*),Tao CHEN~(2*),Jing WANG~1,Yun-Qing LI~2,Jing-Shi TANG~1 1 Department of Physiology and Pathophysiology,Xi'an Jiaotong University School of Medicine,Key Laboratory of Environment and Genes Related to Diseases,Ministry of Education,Xi'an 710061 2 Department of Anatomy and K.K.Leung Brain Research Centre,The Fourth Military Medical University,Xi'an 710032; 关键词：5-HT; 文献传递

5-HT1A受体参与腹外侧眶皮层内5-HT诱发的抗伤害效应: 2008年; 为了明确5-HT参与腹外侧眶皮层(VLO)的抗伤害效应以及VLO内的5-HT1A受体与该效应之间的关系,本研究采用浅麻大鼠,以甩尾反射潜伏期(TFL)为指标,观察VLO内微量注射5-HT和选择性5-HT1A受体拮抗剂p-MPPI对TFL的影响。结果显示:VLO内微量注射5-HT(2.0、5.0、10.0μg)可剂量依赖性抑制辐射热诱发的TFL;而VLO内预先5min微量注射5-HT1A受体拮抗剂p-MPPI(0.2μg)可拮抗5-HT(10.0μg)诱发的抗伤害效应。本研究的结果提示5-HT参与VLO内的抗伤害效应,而该效应可能由5-HT1A受体介导。; 屈超玲贾红霍福权; 关键词：5-HT 5-HT1A受体抗伤害效应

μ-opioid presynaptic inhibition of GABA release in rat ventrolateral orbital cortex neurons: Previous studies have indicated that the ventrolateral orbital cortex(VLO) is involved in modulation of nocice...; Chao-Ling QU~1,Fu-Quan HUO~1,Fen-Sheng HUANG~1,Yun-Qing LI~2,Jing-Shi TANG~1 1 Department of Physiology and Pathophysiology,Xi'an Jiaotong University School of Medicine,Key Laboratory of Environment and Genes Related to Diseases,Ministry of Education,Xi'an 710061 2 Department of Anatomy and K.K.Leung Brain Research Centre,The Fourth Military Medical University,Xi'an 710032; 关键词：DAMGO CTOP; 文献传递

腹外侧眶皮层内吗啡诱发的抗伤害效应的机制被引量：2: 2008年; 目的:明确腹外侧眶皮层(VLO)内微量注射吗啡产生抗伤害效应的机制是否通过GABA能调制介导的.方法:以辐射热诱发的大鼠甩尾反射潜伏期的变化作为伤害性反应的指标.结果:VLO内微量注射选择性GABAA受体拮抗剂荷包牡丹碱(100,200,500ng)可剂量依赖性抑制辐射热诱发的大鼠尾反射潜伏期.VLO内微量注射吗啡(5.0μg)10min后,同一部位注射荷包牡丹碱(100ng)可增加吗啡诱发的抗伤害效应,而VLO内微量注射吗啡(5.0μg)10min后,同一部位注射GABAA受体激动剂muscimol(250ng)可减弱吗啡诱发的抗伤害效应.结论:VLO内GABAA受体参与吗啡诱发的抗伤害效应,吗啡可能直接抑制了GABA能中间神经元,使VLO至PAG的投射神经元去抑制,间接激活了脑干下行抑制,在脊髓水平抑制了伤害性信息的输入而实现的.; 屈超玲贾红霍福权; 关键词：吗啡抗伤害效应

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国家自然科学基金(30570592)