In this paper,the automorphism group of G is determined,where G is a 4 × 4 upper unitriangular matrix group over Z.Let K be the subgroup of AutG consisting of all elements of AutG which act trivially on G/G,G /ζG and ζG,then (i) InnG ■ K ■ AutG;(ii) AutG/K≌=G_1×D_8×Z_2,where G_1=(a,b,c|a^4=b^2=c^2=1,a^b=a^(-1),[a,c]= [b,c]=1 ;(iii) K/Inn G≌=Z×Z×Z.