Four new ternary complexes: [Cu(IP)(L-Val)(H2O)]ClO4·1.5H2O(1), [Cu(IP)(L-Leu)(H2O)]ClO4(2), [Cu(IP)(L-Tyr)(H2O)]ClO4·H2O(3) and [Cu(IP)(L-Trp)(H2O)]ClO4·1.5H2O(4) have been synthesized and character/zed by elementa/analysis, molar conductivity, infrared absorption spectroscopy, electronic absorption spectroscopy and cyclic voltammetry, where IP=imidazo[4,5-f][1,10] phenanthroline, L-Val=L-valinate, L-Leu=L-leucinate, L-Tyr=L-tyrosinate and L-Trp=L-tryptophanate. Complex 3 was structurally characterized by X-ray diffraction method, which crystallizes in orthorhornbic space group P21212 in a unit cell of dimensions a=3.0567(4) nm, b=0.74079(9) nm, c= 1.06198(13) nm, V=2.4047(5) nm^3, Z=4,μ=0.1084 cm^-1. The SOD-like activities of catalytic disrnutation of superoxide anions (O2^-· ) by the complexes were determined by means of modified nitroblue tetrazolium (NBT) photoreduction. The IC50 values of complexes 1, 2, 3 and 4 are 0.072, 0.147, 0.429 and 0.264 μmol·L^-1, respectively
Three complexes of Mn(Ⅱ)with L-amino acid[L-Isoleucine(L-Ile),L-Methionine(L-Met),L-Tryptophan(L-Trp)]were synthesized and characterized by elemental analysis,infrared spectra and gravithem metrical analyses.The catalytic activity of the three complexes for disproportionation of O2-was determined by NBT method.The result shows that the complexes have a high SOD-like activity,and the KQ values of complexes 1,2 and 3 are 0.78×107mol-1·L·s-1,1.28×107mol-1,and 1.50×107mol-1L·s-1,respectively.
A dinuclear copper(Ⅱ) complex[Cu2(TATP)2(L-Leu)2(CIO4)2]2·2H2Owas synthesized and characterized, where, TATP=1,4,8,9-tetraazatriphenylene, and L-Leu=L-leucinate. The complex was crystallized in the triclinic space group P1, with two independent molecules in a unit cell. Two Cu(Ⅱ) ions in each complex [Cu2(TATP)2(L-Leu)2(CIO4)2] molecule were found to be in different coordination geometries, i.e., Cu2 or Cu4 of a distorted square-pyramidal geometry coordinated with two nitrogens of TATP, the amino nitrogen and one carboxylate oxygen of L-Leu and one oxygen of perchlorate, and Cul or Cu3 with an octahedral geometry coordinated with the above stated similar coordinated atoms, and another carboxylate oxygen of L-Leu coordinating to Cu2 or Cu4. The complex can interact with CT-DNA by an intercalative mode and cleave pBR322 DNA in the presence of ascorbate.