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国家自然科学基金(31070905)

作品数:5 被引量:18H指数:3
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Similarity representation of pattern-information fMRI被引量:2
2013年
Representational similarity analysis (RSA) is a rapidly developing multivariate platform to investigate the structure of neural activities. Similarity/dissimilarity is the core concept of RSA, realized by the construction of a representational dissimilarity matrix, that addresses the closeness/distance for each pair of research elements (e.g., one minus the correlation between the brain responses to 2 different stimuli) and in turn, constitutes a multivariate pattern as its analytic foundation. This approach is also welcome for its sensitivity in detecting subtle differences of distributed experimental effects in the brain. Importantly, RSA is not only an experimental tool but a promising data-analytical framework that can integrate cross-modal imaging signals, explore brain-behavior link, and verify computational models according to measured neural activities. RSA substantiates its integrative power by relating similarity structure in one domain (e.g., stimulus features) to that in another domain (e.g., neural activities). This review summarizes dissimilarity/similarity definition of RSA, introduces how to derive the dissimilarity structure in neural response pattern, and carry out connectivity analysis based on RSA platform. Several recent advances are highlighted, such as the extraction of across-subjects regularity, cross-validation of brain reactivity in human beings and monkeys, the incorporation of computational models and behavioral profiles into RSA. Voxel receptor field modeling, another promising multivariate tool of pattern elucidation, is presented and compared. The application of RSA is expected to surge and extend in many fields of neuro-science, computation, psychology and medicine. We also discuss the limitations of RSA and some critical questions that need to be addressed in future research.
XUE ShaoWeiWENG XuChuHE ShengLI DianWen
关键词:FMRI神经活动权力结构
Recent developments in multivariate pattern analysis for functional MRI被引量:5
2012年
Multivariate pattern analysis(MVPA) is a recently-developed approach for functional magnetic resonance imaging(fMRI) data analyses.Compared with the traditional univariate methods,MVPA is more sensitive to subtle changes in multivariate patterns in fMRI data.In this review,we introduce several significant advances in MVPA applications and summarize various combinations of algorithms and parameters in different problem settings.The limitations of MVPA and some critical questions that need to be addressed in future research are also discussed.
Zhi YangFang FangXuchu Weng
关键词:FMRI
颈内动脉内注射丙泊酚定侧语言区和评价半球记忆功能被引量:2
2012年
目的在目前阿米妥普遍缺乏的背景下,探讨应用丙泊酚替代阿米妥进行颈内动脉注射进行Wada试验,定侧语言区和评价半球记忆功能的价值。方法14例拟接受外科治疗的药物难治性部分性癫痫患者纳入本研究。在数字减影脑血管造影条件下,通过双侧颈内动脉分别注射丙泊酚,以麻醉半球对侧肢体肌力达到0级以及患者出现向对侧凝视作为药物充分显效的标志。观察患者麻醉后即刻出现的语言改变,并在获取患者注意力后,依次给予视觉和听觉记忆任务,待肌力完全恢复后,给予任务再认,从而评价麻醉半球的语言功能和记忆功能,并记录患者的不适表现。结果14例患者均成功定侧了语言半球,其中3例为双侧语言半球,9例为左侧语言优势半球,2例为右侧语言优势半球。同时评价了13例患者的半球记忆功能,拟切除颞叶内侧对侧半球均能维持67%以上记忆功能。在药物注射后观察到注射同侧眼痛、面部肌肉痉挛,发笑,对侧肢体不自主运动,均为一过性表现。结论颈内动脉注射丙泊酚能安全有效地定侧语言半球和评价半球记忆功能。丙泊酚可以作为一种可选择的药物进行Wada试验。
任连坤田朝晖张志勇陈佳吴冬燕李小璇张伟赫荣培薛爽焦劲松
关键词:语言二异丙酚颈内动脉
短时反转恢复序列在诊断海马硬化中的应用被引量:4
2012年
目的探讨短时反转恢复(STIR)序列在诊断海马硬化(HS)中的临床应用价值。方法21例经常规MRI扫描排除了占位性和损伤性病变的内侧颞叶癫痫患者纳入研究。采用STIR技术,进行冠状位、轴位和矢状位成像,依照海马体积的缩小、信号改变、海马内部结构的丧失和侧脑室颞角扩大的海马硬化判断标准,分析比较常规MRI序列和STIR序列的成像结果,并进一步分析6例接受手术切除治疗患者海马的影像-病理相关性。结果常规MRI序列能较好地显示海马的体积改变和信号的改变,但是对于海马内部结构显示不清。经常规MRI诊断14例(66.7%)为一侧HS,4例为一侧可疑HS。而STIR序列能够清晰显示海马内部结构,正常海马可以观察到下托到CA1区并延续到CA2区的线样稍低信号影,呈现“C”字征;而在HS中此信号消失,同时在CA4区,呈现低信号区域。18例(85.7%)经STIR诊断为HS。来自6例手术患者的影像-病理分析显示,“C”字征信号消失与CA1区锥体神经细胞脱失相关,而CA4区低信号则反映了胶质增生。结论STIR序列的高分辨率可以可靠地显示海马的细微解剖结构,优于常规的MRI序列,在诊断HS中具有重要价值。
任连坤陈佳于炎冰李锐吴冬燕李小璇董明睿焦劲松洪闻
关键词:海马癫痫颞叶诊断显像
Selectivity of N170 in the left hemisphere as an electrophysiological marker for expertise in reading Chinese被引量:5
2012年
Objective The left-lateralized N170, an event-related potential component consistently shown in response to alphabetic words, is a robust electrophysiological marker for reading expertise in an alphabetic language. In contrast, such a marker is lacking for expertise in reading Chinese, because the existing results about the lateralization of N170 for Chinese characters are mixed, reflecting complicated factors such as top-down modulation that contribute to the relative magnitudes of N170 in the left and right hemispheres. The present study aimed to explore a potential electrophysiological marker for reading expertise in Chinese with minimal top-down influence. Methods We recorded N170 responses to Chinese characters and three kinds of control stimuli in a content-irrelevant task, minimizing potential top-down effects. Results Direct comparison of the N170 amplitude in response to Chinese characters between the hemispheres showed a marginally significant left-lateralization effect. However, detailed analyses of N170 in each hemisphere revealed a more robust pattern of left-lateralization - the N170 in the left but not the right hemisphere differentiated Chinese characters from control stimuli. Conclusion These results suggest that the selectivity of N170 (a greater N170 in response to Chinese characters than to control stimuli) within the left hemisphere rather than the hemispheric difference of N170 with regard to Chinese characters is an electrophysiological marker for expertise in reading Chinese.
Jing ZhaoSu LiSi-En LinXiao-Hua CaoSheng HeXu-Chu Weng
关键词:N170
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