The radial deformation design of turbine disk seriously influences the control of gas turbine high pressure turbine(HPT) blade-tip radial running clearance(BTRRC). To improve the design of BTRRC under continuous operation, the nonlinear dynamic reliability optimization of disk radial deformation was implemented based on extremum response surface method(ERSM), including ERSM-based quadratic function(QF-ERSM) and ERSM-based support vector machine of regression(SR-ERSM). The mathematical models of the two methods were established and the framework of reliability-based dynamic design optimization was developed. The numerical experiments demonstrate that the proposed optimization methods have the promising potential in reducing additional design samples and improving computational efficiency with acceptable precision, in which the SR-ERSM emerges more obviously. Through the case study, we find that disk radial deformation is reduced by about 6.5×10–5 m; δ=1.31×10–3 m is optimal for turbine disk radial deformation design and the proposed methods are verified again. The presented efforts provide an effective optimization method for the nonlinear transient design of motion structures for further research, and enrich mechanical reliability design theory.