In this paper, we prove some results concerning blow-up of viscous compressible reactive （selfgravitating） flows when the initial density is compactly supported and the other initial value satisfy proper conditions. It extends the work of Xin and Cho to the case of viscous compressible reactive self-gravitating flows equations. We control the lower bound of second moment by total energy and obtain the precise relationship between the size of the support of initial density and the existence time.
