Effects of Reynolds(Re)number and Schmidt(Sc)number on the flow structures and variable density mixing are numerically investigated through the canonical shock cylindrical bubble interaction.By determining the viscosity and diffusivity within a wide range,the controlling parameters,total vortex circulation,and compression rate,are conservative under a broad range of Re and Sc numbers(Re≈10^(3)-10^(5)and Sc≈0.1-5)in the same shock Mach(Ma)number condition(Ma=2.4).As for the Re number effect,the circulation of secondary baroclinic vorticity(SBV),induced by the main vortex centripetal acceleration,is observed to be higher in high Re number and vice versa.Based on the vorticity transport equation decomposition,a growth-inhibition vorticity dynamics balance mechanism is revealed:the vorticity viscous term grows synchronously with baroclinic production to inhibit SBV production in low Re number.By contrast,the viscous term terminates the baroclinic term with a time lag in high Re number,leading to the SBV production.Since the SBV reflects the local stretching enhancement based on the advection-diffusion equation,mixing is influenced by the Sc number in a different behavior if different Re numbers are considered.The time-averaged variable density mixing rate emerges a scaling law with Sc number asχ^(∗)=β·Sc^(−α),where the coefficientβ∼Re−0.2 and the scaling exponentα∼Re−0.385.The understanding of Re number and Sc number effect on variable density mixing provides an opportunity for mixing enhancement from the perspective of designing the viscosity and diffusivity of the fluid mixture.