目的探讨达克罗宁胶浆联合利多卡因表面麻醉应用于抑制甲状腺手术全麻插管时心血管反射的效果。方法采用随机数字表法将100例全麻甲状腺手术患者分为实验组与对照组,各50例。实验组患者口咽部预先含服盐酸达克罗宁胶浆10 m L,气管插管前口咽部、声门下以2%利多卡因5 m L局部喷洒,对照组患者气管插管前口咽部、声门下以2%利多卡因5 m L局部喷洒。记录并比较2组诱导前、利多卡因表麻时、插管后即刻血流动力学指标。结果与对照组相比,实验组插管反应显著更轻微,各时点血流动力学指标显著更稳定,差异有统计学意义(P <0. 01)。结论在甲状腺手术全麻插管时联合运用达克罗宁胶浆与利多卡因表面麻醉,可有效抑制心血管反射,使血流动力学更稳定。
The brainstem is a major site in the central nervous system involved in the processing of the cardiovascular reflexes such as the baroreflex and the peripheral chemoreflex. The nucleus tractus solitarius and the rostral ventrolateral medulla are 2 important brainstem nuclei, and they play pivotal roles in autonomic cardiovascular regulation. Angiotensin II is one of the neurotransmitters involved in the processing of the known that one of the mechanisms by which angiotensin II exerts cardiovascular reflexes within the brainstem. It is well- its effect is via the activation of pathways that generate reactive oxygen species （ROS）. In the central nervous system, ROS are reported to be involved in several pathological dis- eases such as hypertension, heart failure and sleep apnea. However, little is known about the role of ROS in the processing of the cardiovascular reflexes within the brainstem. The present review mainly discussed some recent findings documenting a role for ROS in the processing of the baroreflex and the peripheral chemoreflex in the brainstem.
