牙周组织缺损是牙周炎治疗的难点,传统治疗方法难以有效恢复牙周组织的结构和功能。引导组织再生术(Guided Tissue Regeneration, GTR)作为一种再生医学技术,利用生物屏障膜隔离牙周缺损区域,为牙周组织再生创造有利空间,从而促进牙周功能的恢复。可吸收生物膜因其无需二次手术取出、生物相容性好、可控降解等优势,成为GTR的理想材料。本文综述了不同种类可吸收生物膜在GTR中的研究进展,重点关注其理化特性、生物学效应以及临床应用效果,并探讨了该领域目前存在的挑战及未来研究方向,旨在为GTR的临床实践提供指导并推动治疗方式优化。Periodontal tissue defects, characterized by gingival recession and alveolar bone loss, pose significant challenges in periodontitis treatment, as conventional therapies often fail to fully restore tissue structure and function. Guided tissue regeneration (GTR) offers a regenerative medicine approach, employing barrier membranes to isolate the defect site and foster a conducive environment for periodontal tissue regeneration, ultimately promoting functional recovery. Resorbable membranes, owing to their advantages of eliminating the need for a second surgical procedure, coupled with favorable biocompatibility and controlled degradation profiles, have emerged as ideal GTR materials. This review summarizes the research progress of various resorbable membranes in GTR, focusing on their physicochemical properties, biological effects, and clinical outcomes. Furthermore, it explores current challenges and future research directions in this field, aiming to inform and enhance clinical practice in GTR.
