目的:探讨不同左室射血分数(LVEF)水平与心力衰竭人群肾功能障碍的关联。方法:以2006年至2018年期间参与开滦集团健康体检并于2020年12月31日前首次确诊心力衰竭的个体为研究对象,按照LVEF Objective: To investigate the association between different levels of left ventricular ejection fraction (LVEF) and renal dysfunction in patients with heart failure. Methods: Individuals who participated in the Kailuan Group health examinations between 2006 and 2018 and were first diagnosed with heart failure by December 31, 2020, were included as the study population. Participants were categorized into three groups based on LVEF levels: LVEF < 40%, 40% ≤ LVEF < 50%, and LVEF ≥ 50%. LVEF was used as the independent variable, and the presence of renal dysfunction was used as the dependent variable. A binary logistic regression model was constructed to calculate odds ratios (ORs) and their 95% confidence intervals (CIs). Subgroup analyses were performed according to age, sex, and obesity. Additionally, sensitivity analyses were conducted by excluding individuals with a history of hypertension, diabetes, myocardial infarction, or pre-existing chronic kidney disease (CKD) to verify the robustness of the results. Results: A total of 3272 participants were included in this study, of whom 2837 (86.7%) were male, with a mean age of 68.01 ± 10.99 years. Logistic regression analysis showed that, compared with the reference group (LVEF ≥ 50%), the odds ratios (ORs) for renal dysfunction were 1.73 (95% CI: 1.31~2.29) in the 40% ≤ LVEF < 50% group and 2.42 (95% CI: 1.72~3.41) in the LVEF < 40% group. Subgroup analysis revealed that, except for the female subgroup, which showed no statistically significant difference, the results were consistent with the overall analysis across all other subgroups. Conclusion: The risk of renal dysfunction increases progressively with the decline in LVEF among patients with heart failure.
目的探讨178例高血压病患者收缩压(SBP)昼夜节律与血压变异性(BPV)及其左室射血分数(LVEF)的关系。方法多中心回顾性研究。按纳入标准选取2020年1月-2022年1月178例原发性高血压病患者作为观察对象,均行24 h动态血压监测及超声心动图检查。收集患者昼夜节律、BPV、心脏超声心动图等相关数据,探讨SBP昼夜节律与BPV及LVEF关系。结果178例患者中,昼夜节律降低患者>昼夜节律存在患者>昼夜节律倒置患者>昼夜节律消失患者;SBP昼夜节律消失患者年龄低于倒置患者[(63.8±14.5)岁比(71.5±9.4)岁,P<0.05];SBP昼夜节律存在患者24 h SBP标准差低于倒置患者[(13.1±2.8)mmHg比(15.2±3.1)mmHg,P<0.05];SBP昼夜节律存在患者LVEF高于倒置患者[(68.2±6.5)%比(62.9±9.6)%,P<0.05]。结论SBP昼夜节律倒置时BPV最大,LVEF最低。
