子宫颈癌是发生于子宫颈上的恶性肿瘤,根据流行病学的调查,其女性发病率在发展中国家居首位。放疗是宫颈癌治疗的手段之一。与根治性手术相比,放疗治疗适用于有生育要求的女性,适用于对中晚期不能手术或者不能耐受手术的患者,适用于根治性手术后的补充治疗,防止其复发转移。放疗的耐受性良好,但是也存在一定的弊端,在放疗照射时腹腔其他组织受累,其结肠、直肠等会发生组织学改变,常出现放射性膀胱炎、直肠炎、下肢淋巴水肿等毒副反应。西医治疗这些并发症手段单一,效果不理想。我国传统医学秉承整体观念,辨证论治,不仅对其并发症有良好的治疗效果,而且能改善机体整体状态,提高患者免疫力。在放疗的毒副反应治疗上,中医疗法和西医疗法同等重要。Cervical cancer is a malignant tumor occurring on the cervix, and according to epidemiological investigation, the incidence of cervical cancer in women is the first in developing countries. Radiotherapy is one of the treatment methods for cervical cancer. Compared with radical surgery, radiotherapy is suitable for women with fertility requirements, for patients who are inoperable or cannot tolerate surgery in the middle and late stages, and for supplementary treatment after radical surgery to prevent recurrence and metastasis. Radiotherapy is well tolerated, but it also has some drawbacks. Other tissues of the abdominal cavity are involved during radiotherapy, histological changes occur in the colon and rectum, and toxic side effects such as radiation cystitis, proctitis, and lymphedema of the lower extremities are often observed. Western medicine treatment of these complications means a single, and the effect is not ideal. Chinese traditional medicine, adhering to a holistic perspective and a syndrome differentiation treatment approach, not only has a good effect on the treatment of complications, but also can improve the overall state of the
目的:探讨美沙拉嗪灌肠对宫颈癌放疗所致急性放射性直肠炎患者的影响。方法:选取2021年10月至2023年10月我院收治的124例宫颈癌放疗所致急性放射性直肠炎患者,随机分成两组(n=62)。对照组给予康复新液灌肠,观察组给予美沙拉嗪灌肠。治疗3 w后评估临床症状评分、直肠损伤程度及生活质量综合评定问卷(General Quality Of Life Inventory-74,GQOLI-74),并采用酶联免疫吸附法检测检测血清C反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子-α(Tumor necrosis factor,TNF-α)、白细胞介素-6(Interleukin-6,IL-6)水平。结果:观察组治疗后各项临床症状评分、直肠损伤程度分级及血清CRP、TNF-α、IL-6检测结果低于对照组(P<0.05);观察组治疗后GQOLI-74各项评分高于对照组(P<0.05)。结论:美沙拉嗪灌肠能够有效改善宫颈癌放疗所致急性放射性直肠炎患者的临床症状、直肠损伤程度和生活质量。
