目的 探讨退役人员咖啡因摄入及对夜间睡眠时长的影响。方法 目前仅美国国家健康与营养调查(national health and nutrition examination survey,NHANES)提供退役人员公开数据。只有2009~2014年包括尿咖啡因数据,但只有2009~2010年周期数据检测方法一致。因此本研究纳入806名2009~2010年NHANES被试者,根据是否服过兵役分为退役组(n=221)、未服役组(n=594)。分析美军退役人员与未服役人员尿咖啡因及其主要代谢物含量差异及与夜间睡眠时长的相关性。结果 退役人员目前夜间睡眠时长短于未服役人员且组间差异有统计学意义(P<0.05)。退役人员尿1-甲基尿酸(1-MU)和咖啡因含量高于未服役人员且组间差异有统计学意义(P<0.05)。退役人员尿1-MU含量与夜间睡眠时长呈负相关(r=-0.226;P<0.05)。多元线性回归分析表明,校正了年龄、教育水平、种族和吸烟后退役人员尿1-MU含量与夜间睡眠时长呈负相关(β=-0.226;P<0.05)。结论 美军退役人员咖啡因摄入量降低夜间睡眠时长,为我国退役军人的睡眠健康提供理论证据和借鉴。
The two mltabolites of caffeine, 5 - acetylamino - 6 - formylamino - 1 - mlthyhuracil (AFMU)and 1 -mlthylxanthine(IX),in urine collected from 190 health Chinese volunteers were analyzed by HPLC. The peak height ratio of AFMU/IX was used to determine the acetylators phenotypes. The results showed that 73. 68% of the subjects could be classified as fast acetylators which is similar to the ratio previousy reported for Asian with isoniazide and sulfamlthazine as the pharmacological probes. Phenotyping with caffeine as a probe via analyzing its urinary metabolites by HPLC is shown to be simple and fast. The analyzing precision is (CV% )2. 2% - 4. 4% and the rate of recovery is 94% - 95 %.
